• Staff chemist at the General Electric Corporate Research Center in Schenectady, NY (1988-1991)
  • Post-doctoral researcher at the University of Florida College of Pharmacy (1991-1995)
  • Assistant professor in the UCF Chemistry Department (1995-2000)
  • Associate professor in the UCF Chemistry Department (2000-2006)
  • Full professor in the UCF Chemistry Department (2006-2008)
  • Full professor in the UCF College of Medicine (2008-present)


For a complete list of publications, please click here.


Recent Publications: 


  1. A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors. Molly C. Peters, Allyson Minton, Otto Phanstiel IV, and Susan K. Gilmour. Med. Sci. 2018, 6, 3. doi:10.3390/medsci6010003
  2. Difluoromethylornithine Combined with a Polyamine Transport Inhibitor is Effective against Gemcitabine Resistant Pancreatic Cancer. Gitto, Sarah; Pandey, Veethika; Oyer, Jeremiah; Copik, Alicja; Hogan, Frederick; Phanstiel, Otto; Altomare, Deborah. Mol Pharmaceutics 2018, 15, 369-376.
  3. Targeting polyamine transport in Trypanosoma cruzi. Chantal Reigada, Otto Phanstiel IV, Mariana R. Miranda, Claudio A. Pereira. Eur. J. Med. Chem. 2018, 147, 1-6.
  4. An Overview of Polyamine Metabolism in Pancreatic Ductal Adenocarcinoma. Otto Phanstiel IV. Int. J. Cancer 2018, 142, 1968-1976. doi:10.1002/ijc.31155
  5. Antibiotic Adjuvants: Make Antibiotics Great Again! Hana Douafer, Véronique Andrieu, Otto Phanstiel IV, Jean Michel Brunel. J. Med. Chem. 2019, 62, 8665-8681.
  6. FP028: Calcium Sensor Receptor Modulation is a Mechanism for the Medicinal Effects of Plant Derived Polyphenols. Edward Ross, Alexander Bosak, Dwight Towler, Timothy Gilbertson, Bradley Willenberg, Alicia Willenberg, Naima Dahir, Otto Phanstiel. Nephrology Dialysis Transplantation, 2019, 34, Suppl.1, June 13, 2019,
  7. Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing. Chantal Reigada, Melisa Sayé, Otto Phanstiel IV, Edward Valera-Vera, Mariana Reneé Miranda, Claudio A. Pereira. Front. Med. 2019, 6, No. 256, Nov 8, 2019
  8. Serendipitous Discovery of Leucine and Methionine Depletion Agents during the Search for Polyamine Transport Inhibitors. Chelsea Massaro, Jenna Thomas, Houssine Ikhlef, Sharifa Dinara, Sara Cronk, Holly Moots, and Otto Phanstiel IV, J. Med. Chem. 2020, 63, 2814-2832.
  9. Polyamine Blocking Therapy Decreases Survival of Tumor-Infiltrating Immunosuppressive Myeloid Cells and Enhances the Anti-Tumor Efficacy of PD-1 Blockade. Susan K. Gilmour, Eric T Alexander, Kelsey Mariner, Julia Donnelly, and Otto Phanstiel. Molecular Cancer Therapeutics, 2020, 19, 2012-2022. 
  10. The involvement of polyamine uptake and synthesis pathways in the proliferation of neonatal astrocytes. Christian J. Malpica-Nieves, David E. Rivera-Aponte, Flavia A. Tejeda-Bayron, Angel M. Mayor, Otto Phanstiel, Rüdiger W. Veh, Misty J. Eaton, Serguei N. Skatchkov. Amino Acids 2020, 52, 1169-1180.


Education & Specialties

  • Ph.D. (Organic Chemistry): August 1988, University of Florida, Gainesville, FL
  • B.S. in Chemistry: May 1984, Duke University, Durham, NC


  • Organic chemistry
  • Medicinal chemistry
  • Drug design
  • Biochemistry


  • UCF Biomedical Sciences Ph.D. program (BSC6432, IDS 7980, IDS 7919)
  • UCF MD program (Cellular Function and Medical Genetics module)

Research Interests:

  • Pancreatic cancer
  • Polyamine metabolism and cancer growth
  • Cancer metabolism
  • Polyamine transport in human cells
  • Snyder Robinson Syndrome
  • Mitochondrial disease