Hatem Kaseb, MD, PhD, MPH

Assistant Professor of Pathology

Course Director, Foundations Module

Dr. Hatem Kaseb is an academic pathologist and physician-scientist with specialized expertise in Hematopathology, Gynecologic Pathology, and Medical Education. He currently serves as an Assistant Professor of Pathology in the Department of Clinical Sciences at the University of Central Florida (UCF) College of Medicine. In his clinical role, he practices as an attending pathologist within the HCA Healthcare East Florida Division, where he oversees complex hematopathology and oncologic cases, directs diagnostic sign-out, and serves on the hospital tumor board. At UCF, Dr. Kaseb is involved in multiple courses and he is currently the Course Director for the Foundations Module, leading foundational medical education and curriculum development for first and second-year medical students.

Dr. Kaseb’s academic and clinical achievements have been recognized with several prestigious honors, including the UCF College of Medicine Clinical Excellence Award and the Early Career Investigator Award for Achievement in Research. He also previously received the Chair’s Challenge Award for Research from the Yale School of Medicine. He is board-certified in Anatomic and Clinical Pathology as well as Hematopathology by the American Board of Pathology.

His educational background includes a medical degree from Cairo University, followed by a PhD in Human Genetics and an MPH in Public Health Genetics from the University of Pittsburgh. His doctoral research focused on cancer genetics, head and neck cancer,  and the molecular mechanisms of tumorigenesis. Dr. Kaseb completed his residency training in Anatomic and Clinical Pathology at Yale New Haven Hospital and subsequently pursued fellowship training in Hematopathology at the Cleveland Clinic.

Dr. Kaseb is a prolific researcher and educator, having authored numerous peer-reviewed articles in high-impact journals such as Nature Communications, Gene Chromosome and Cancer, Cancer Cytopathology, and the American Journal of Surgical Pathology. His research interests span medical education, myeloid neoplasms, gut microbiome, head and neck cancer biology, bone sarcoma pathogenesis, and the integration of artificial intelligence in medical education. He serves as an Associate Editor for Genetic Testing and Molecular Biomarkers and is a dedicated mentor to medical students through the UCF FIRE (Focused Research Inquiry Experience) program. Dr Kaseb is also currently serving and/or have served in local and national committees such as the American Society for Clinical Pathology (ASCP), Association of Professors of Human and Medical genetics (APHMG) and Florida Society of Pathology (FSP). Dr. Kaseb is an active Fellow of the College of American Pathologists (CAP) and a member of the United States and Canadian Academy of Pathology (USCAP).

Select Publications

Sonal S, Kaseb H. An Unusual Case of Diffuse Large B Cell Lymphoma of the Common Bile Duct Extending to the Common Hepatic Duct. ACG Case Rep J. 2025 Jun;12(6):e01734. PMID: 40475280.

Sapountzi E, Crane G, Gibson J, Kaseb H. VEXAS Syndrome: A Perspective Focus on Genetics and Hematological Manifestations. Genet Test Mol Biomarkers. 2025 Mar;29(3):49-53. doi: 10.1089/gtmb.2024.0426. Epub 2025 Mar 11. PMID: 40064544

Kaseb H, Davey DD. Use of ultrasensitive RNA in situ hybridization for kappa and lambda light chains assists in the differential diagnosis of B-cell non-Hodgkin and Hodgkin lymphomas in cytopathology practice. Cancer Cytopathol. 2024 Nov;132(11):675-677. doi: 10.1002/cncy.22834. Epub 2024 Jun 2. PMID: 38824408

Kaseb H, Tan C, Townsend JP, Costa J, Laskin WB. Genomic Landscape of Osteosarcoma of Bone in an Older-Aged Patient Population and Analysis of Possible Etiologies Based on Molecular Signature. Genet Test Mol Biomarkers. 2024 Sep;28(9):351-359. doi: 10.1089/gtmb.2024.0080. Epub 2024 Jul 25. PMID: 39052504

Kaseb H, Crane G, Gibson J. TP53-Mutated Myelodysplastic Syndrome: A Diagnostic Approach in Different Clinical Settings. Genet Test Mol Biomarkers. 2024 Jun;28(6):219-222. doi: 10.1089/gtmb.2024.0131. Epub 2024 May 6. PMID: 38708593

Kaseb H, Visconte V, Socha DS, Crane GM, Durkin L, Cook JR, Maciejewski JP, Hsi ED, Rogers HJ. The clinicopathologic significance of NPM1 mutation and ability to detect mutated NPM1 by immunohistochemistry in non-AML myeloid neoplasms. Genes Chromosomes Cancer. 2023 Oct;62(10):573-580. doi: 10.1002/gcc.23139. Epub 2023 Apr 4. PMID: 36959701

Kaseb H, Wang Z, Cook JR. Am J Surg Pathol. 2022 Aug 1;46(8):1078-1083; PMID: 35195576; 2022 Feb 24. Ultrasensitive RNA In Situ Hybridization for Kappa and Lambda Light Chains Assists in the Differential Diagnosis of Nodular Lymphocyte-predominant Hodgkin Lymphoma

Kaseb HO, Fohrer-Ting H, Lewis DW, Lagasse E, Gollin SM.; Exp Cell Res. 2016 Oct 15;348(1); PMID: 27619333; Epub 2016 Sep 9. Identification, expansion and characterization of cancer cells with stem cell properties from head and neck squamous cell carcinomas

Hatem O Kaseb, Dale W Lewis, William S Saunders, Susanne M Gollin. Genes Chromosomes Cancer. 2016 Sep;55(9):694-709. PMID: 27123539. Epub 2016 Jun 23. Cell division patterns and chromosomal segregation defects in oral cancer stem cells

O’Keefe SJ, Li JV, Lahti L, Ou J, Carbonero F, Mohammed K, Posma JM, Kinross J, Wahl E, Ruder E, Vipperla K, Naidoo V, Mtshali L, Tims S, Puylaert PG, DeLany J, Krasinskas A, Benefiel AC, Kaseb HO, Newton K, Nicholson JK, de Vos WM, Gaskins HR, Zoetendal EG.; PMID: 25919227; Nat Commun. 2015 Apr 28;6:6342. Fat, fibre and cancer risk in African Americans and rural AfricansKaseb H, Hudnall. S. BCR-ABL1-like. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/leukemiaprebbcrabl1like.html