Hatem Kaseb, MD, PhD, MPH

Biography

Dr. Hatem Kaseb is a pathologist with a special interest in Hematopathology, Gynecological Pathology and Medical Education. He is board-certified in Anatomic/Clinical Pathology and Hematopathology by the American Board of Pathology. Dr. Kaseb began his medical career at Cairo University School of Medicine. He then completed his PhD in the department of Human Genetics in the University of Pittsburgh. Dr. Kaseb completed his pathology residency at Yale New Haven Hospital  in New Haven, Connecticut; followed by a Hematopathology Fellowship in the Cleveland Clinic, Cleveland, Ohio. Prior to being recruited to UCF, Dr Kaseb was an attending Pathologist in University of Pittsburgh Medical Center (UPMC). 

His academic efforts are focused on developing and presenting pathology and genetics content. His clinical duties involve patient care and teaching University of Central Florida (UCF) College of Medicine medical students in the UCF Lake Nona Hospital. Dr Kaseb is also currently serving as the Medical Director of Pathology in UCF Lake Nona Hospital.

Dr Kaseb research interests include Myeloid neoplasms, gut microbiome, head and neck cancer biology and bone sarcoma pathogenesis. Dr. Kaseb is a fellow of the College of American Pathologists (CAP) and an active member of multiple medical societies including United States and Canadian Academy of Pathology (USCAP). Dr Kaseb has authored a number of articles and published abstracts in the fields of Pathology, Hematopathology, Cancer biology and Molecular Pathology. Dr Kaseb also serves as reviewer for a number of pathology journals. He is also currently serving as an Associate Editor for the Genetic testing and molecular biomarkers. He also contributed in creating/editing educational content for USMLE study Qbanks and American Society of Clinical Pathology (ASCP).

Select Publications

Sapountzi E, Crane G, Gibson J, Kaseb H. VEXAS Syndrome: A Perspective Focus on Genetics and Hematological Manifestations. Genet Test Mol Biomarkers. 2025 Mar;29(3):49-53. doi: 10.1089/gtmb.2024.0426. Epub 2025 Mar 11. PMID: 40064544

Kaseb H, Davey DD. Use of ultrasensitive RNA in situ hybridization for kappa and lambda light chains assists in the differential diagnosis of B-cell non-Hodgkin and Hodgkin lymphomas in cytopathology practice. Cancer Cytopathol. 2024 Nov;132(11):675-677. doi: 10.1002/cncy.22834. Epub 2024 Jun 2. PMID: 38824408

Kaseb H, Tan C, Townsend JP, Costa J, Laskin WB. Genomic Landscape of Osteosarcoma of Bone in an Older-Aged Patient Population and Analysis of Possible Etiologies Based on Molecular Signature. Genet Test Mol Biomarkers. 2024 Sep;28(9):351-359. doi: 10.1089/gtmb.2024.0080. Epub 2024 Jul 25. PMID: 39052504

Kaseb H, Crane G, Gibson J. TP53-Mutated Myelodysplastic Syndrome: A Diagnostic Approach in Different Clinical Settings. Genet Test Mol Biomarkers. 2024 Jun;28(6):219-222. doi: 10.1089/gtmb.2024.0131. Epub 2024 May 6. PMID: 38708593

Kaseb H, Visconte V, Socha DS, Crane GM, Durkin L, Cook JR, Maciejewski JP, Hsi ED, Rogers HJ. The clinicopathologic significance of NPM1 mutation and ability to detect mutated NPM1 by immunohistochemistry in non-AML myeloid neoplasms. Genes Chromosomes Cancer. 2023 Oct;62(10):573-580. doi: 10.1002/gcc.23139. Epub 2023 Apr 4. PMID: 36959701

Kaseb H, Wang Z, Cook JR. Am J Surg Pathol. 2022 Aug 1;46(8):1078-1083; PMID: 35195576; 2022 Feb 24. Ultrasensitive RNA In Situ Hybridization for Kappa and Lambda Light Chains Assists in the Differential Diagnosis of Nodular Lymphocyte-predominant Hodgkin Lymphoma

Kaseb HO, Fohrer-Ting H, Lewis DW, Lagasse E, Gollin SM.; Exp Cell Res. 2016 Oct 15;348(1); PMID: 27619333; Epub 2016 Sep 9. Identification, expansion and characterization of cancer cells with stem cell properties from head and neck squamous cell carcinomas

Hatem O Kaseb, Dale W Lewis, William S Saunders, Susanne M Gollin. Genes Chromosomes Cancer. 2016 Sep;55(9):694-709. PMID: 27123539. Epub 2016 Jun 23. Cell division patterns and chromosomal segregation defects in oral cancer stem cells

O’Keefe SJ, Li JV, Lahti L, Ou J, Carbonero F, Mohammed K, Posma JM, Kinross J, Wahl E, Ruder E, Vipperla K, Naidoo V, Mtshali L, Tims S, Puylaert PG, DeLany J, Krasinskas A, Benefiel AC, Kaseb HO, Newton K, Nicholson JK, de Vos WM, Gaskins HR, Zoetendal EG.; PMID: 25919227; Nat Commun. 2015 Apr 28;6:6342. Fat, fibre and cancer risk in African Americans and rural Africans

Kaseb H, Hudnall. S. BCR-ABL1-like. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/leukemiaprebbcrabl1like.html.