Dr. Coathup qualified in Medical Cell Biology from the University of Liverpool, United Kingdom in 1992 before furthering her knowledge with a PhD in orthopedic implant fixation. Her research project focused on the conception and development of a novel design of implant for bone cancer patients, a design that has since been used successfully in patients. She carried out and completed her PhD in 1999 at the Institute of Orthopedics, Division of Surgery and Interventional Science, University College London (UCL) based at the internationally-leading Royal National Orthopedic Hospital in Stanmore, UK. She became an Assistant Professor at UCL in 2001, followed by an Associate Professor position before becoming Head of the Center for Tissue and Cell Research at UCL and Divisional Head of Athena SWAN and Women in Science in 2014. In October 2017, Melanie joined the College of Medicine, University of Central Florida as a Professor of Medicine and Director of the Biionix Cluster.
Over the last 24 years, Dr. Coathup has worked in Biomedical Engineering and orthopedic innovation with the view of investigating and applying scientific discovery to improve the treatment and care of patients. During her career and in collaboration with fellow scientists, clinicians, engineers and orthopedic manufacturing companies, her research has focused on improving orthopedic implant fixation and enhancing bone regeneration, focusing on translational themes that include biomaterials, stem cells, the design and follow-up of implants, implant infection and novel synthetic bone graft substitute materials.
Her work includes the development of a novel synthetic bone substitute material Inductigraft® to boost bone repair and regeneration, which is mainly used in spinal fusion surgery and marketed by Baxter Healthcare. Her research excellence has been recognized internationally through her publications and through receiving several prestigious UK, European and International prizes from her peers. She has successfully supervised MD and PhD research students, undergraduate and graduate research projects and examined over 100 graduate theses besides lecturing to undergraduate and graduate students.
- Coathup MJ, Pendengrass CP, Goodship AE, Blunn GW. In Vivo Soft Tissue Models. In: Experimental Research Methods in Orthopaedics and Trauma. Editors, Simpson H and Augut P. Thieme, p356-365, 2015.
- Blunn GW, Coathup MJ. Fixation of Endoprostheses in Tumour Replacement. In: European Surgical Orthopaedics and Traumatology. The EFORT Textbook. Editor, Bentley G. Springer, p4119 – 4133, 2014.
- Coathup MJ, Ahmad S, Maempel JF, Briggs TW, Aston WJ, Skinner JA, Blunn GW. Non-invasive massive growing prostheses reduce infection in paediatric cancer patients. J Orthop Surg (Hong Kong). 2019 Jan-Apr;27(1):2309499019833403. doi: 10.1177/2309499019833403.
- Meeson R, Sanghani A, Coathup MJ, Blunn G. CXCR4 Antagonism to Treat Delayed Fracture Healing. Tissue Eng Part A. 2019 Jan 5.
- Blunn GW, Ferro De Godoy R, Meswania J, Briggs TWR, Tyler P, Hargunani R, Wilson H, Khan I, Marriott T, Coathup MJ. A novel ceramic coating for reduced metal ion release in metal-on-metal hip surgery. J Biomed Mater Res B Appl Biomater. 2018 Nov 17
- Meeson R, Sanghani-Keri A, Coathup M, Blunn G. VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing. J Orthop Res. 2018 Oct 22
- Cheong VS, Fromme P, Mumith A, Coathup MJ, Blunn GW. Novel adaptive finite element algorithms to predict bone ingrowth in additive manufactured porous implants. J Mech Behav Biomed Mater. 2018 Jul 12;87:230-239.
- Sanghani-Kerai A, Osagie-Clouard L, Blunn G, Coathup M. The influence of age and osteoporosis on bone marrow stem cells from rats. Bone Joint Res. 2018 May 5;7(4):289-297.
- Sanghani A, Osagie-Clouard L, Samizadeh S, Coathup MJ, Kalia P, DiSilvio L, Blunn G. CXCR4 has the Potential to Enhance Bone Formation in Osteopenic Rats. Tissue Eng Part A. 2018 Jun 8.
- Osagie-Clouard L, Kaufmann J, Blunn G, Coathup M, Pendegrass C, Meeson R, Briggs T, Moazen M. Biomechanics of Two External Fixator Devices Used in Rat Femoral Fractures. J Orthop Res. 2018
- Sanghani-Kerai A, McCreary D, Lancashire H, Osagie L, Coathup M, Blunn G. Stem Cell Interventions for Bone Healing: Fractures and Osteoporosis. Curr Stem Cell Res Ther. 2018 Apr 10.
- Mumith A, Thomas M, Shah Z, Coathup M, Blunn G. Additive manufacturing. Bone Joint J. 2018 Apr 1;100-B(4):455-460.
Education & Specialties
- BSc (Honors), Medical Cell Biology, The University of Liverpool, UK
- PhD, Orthopedic Implant Fixation, University College of London, UK
- Orthopedic Implant Fixation
- Bone Regeneration
- The Design and Follow-up of Orthopedic Implants.
- Enhancing & Advancing Bone Regeneration, use of Biostimulative materials and Implant Fixation.
- The Use of Mesenchymal Stem Cells and Bone Tissue Engineering.
- Orthopedic Implant Infection
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