Biography

Dinender Singla is Professor of Medicine at the Burnett School of Biomedical Science, College of Medicine, and University of Central Florida. Dr. Singla received his B.Sc. and M.Sc. degrees from Punjabi University, Patiala, India and his Ph.D. from the Post Graduate Institute of Medical Education and Research, Chandrigarh, India. He is involved in the multidisplinary areas of research that is related to stem cells, heart failure, diabetes, inflammation and cardiac regeneration in cell culture and in vivo models. He has published more than 70 peer reviewed papers in high quality journals. He is continuously serving to review the grants for various NIH, AHA, ministry of Italian health, and Hong Kong study sections. He is an Academic Editor for PLos one, Associate Editor for Canadian Journal of Physiology and Pharmacology as well as he is serving on the Editorial board member for different journals such as American Journal of Physiology: Heart and Circulatory. He has reviewed papers for many prestigious high impact journals such as Circulation. Dr. Singla has edited a stem cell biology book. He served as a chair for various scientific meetings throughout the world. He has also organized scientific conferences. After having significant contributions in the cardiovascular scientific field, Dr. Singla received an honor to become a Fellow of the American Heart Association, and the Fellow of International Academy of Cardiovascular Sciences.  Additionally, he has been honored with outstanding contributions in cardiology award by the American Association of Cardiologists of Indian Origin. Dr. Singla is currently an active secretary for International Academy of Cardiovascular Sciences, North American section. Dr. Singla is continuously funded by AHA and/or NIH RO1 grants since 2004.

Recent Publications (2009-2014)

1. Fatma,S, Selby, D.,  Singla, RD, and Singla DK. (2010). Factors Released from Embryonic Stem Cells Stimulate c-kit-FlK-1+ve Progenitor Cells and Enhance Neovascularization. Antioxid Redox Signal. 2010 Dec 15;13(12):1857-65. (Article)
2. Glass, C., Singal PK., Singla DK. (2010). Stem Cells in the Diabetic Infarcted Heart. Heart Fail Rev. 2010 Nov;15(6):581-8. (Article)
3. Singla DK. Stem cells in the infarcted heart. J Cardiovasc Transl Res. 2010 Feb;3(1):73-8. Epub 2009 Nov 20.
4. Singla DK, Singla, RD, Lamm S, Glass, C. (2010) TGF{beta}2 Treatment Enhances Cytoprotective Factors Released from Embryonic Stem Cells and Inhibits Apoptosis in the Infarcted Myocardium. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1442-50.  (Article)
5. Singla DK, Long X, Glass C, Singla, RD., Yan BB. (2011). iPS repair and regenerate infarcted mouse hearts. Mol Pharm. 2011 Oct 3;8(5):1573-81.  (Article)
6. Binbin Yan, Latifa S. Abdelli and Singla DK (2011). Transplanted induced Pluripotent Stem Cells Improve Cardiac Function and induces Neovascularization in the Infarcted Hearts of db/db Mice. Mol Pharm. 2011 Oct 3;8(5):1602-10. (Article)
7. Glass C, Singla DK (2011). microRNA-1 Transfected Embryonic Stem Cells Enhance Cardiac Myocyte Differentiation and Inhibit Apoptosis by Modulating PTEN/Akt Pathway in the Infarcted Heart.  Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H2038-49 (Article)
8. Glass C, Singla DK (2011). ES cells overexpressing microRNA-1 attenuate apoptosis in the injured myocardium Mol Cell Biochem. 2011 Nov;357(1-2):135-41. (Article)
9. Sarah Neel and Singla DK (2011). Transplanted iPS cells in the Steptozotocin-induced Diabetes inhibit apoptosis and improve Cardiac Function. Mol Pharm. 2011 Dec 5;8(6):2350-7. Epub 2011 Nov 4. (Article)
10. Latifa A; Merino, Hilda; Rocher, Crystal; Singla, DK(2012) Cell Therapy in The Heart. Can J Physiol Pharmacol. 2012 Mar;90(3):307-15. Epub 2012 Feb 28. (Article)
11. Singla DK, hmed, A, Singla, R., and Binbin Yan (2012). Embryonic Stem Cells Improve Cardiac Function in Doxorubicin-Induced Cardiomyopathy Mediated through Multiple Mechanisms. Cell Transplant. Cell Transplant. 2012;21(9):1919-30. (Article)
12. Glass C, Singla DK (2012). Overexpression of TIMP-1 in Embryonic Stem Cells Attenuates Adverse Cardiac Remodeling Following Myocardial Infarction. Cell Transplant. Cell Transplant. 2012;21(9):1931-44. (Article)
13. Rocher C, Singla R, Singal PK, Parthasarathy S, Singla DK. Bone morphogenetic protein 7 polarizes THP-1 cells into M2 macrophages. Can J Physiol Pharmacol. 2012 Jul;90(7):947-51. (Article)
14. Merino H, Parthasarathy S, Singla DK. Partial ligation-induced carotid artery occlusion induces leukocyte recruitment and lipid accumulation–a shear stress model of atherosclerosis. Mol Cell Biochem. 2013 Jan;372(1-2):267-73. (Article)
15. Long X, Singla DK. Inactivation of Klf5 by zinc finger nuclease downregulates expression of pluripotent genes and attenuates colony formation in embryonic stem cells. Mol Cell Biochem. 2013 Jun 19. [Epub ahead of print] (Article)
16. Binbin Yan, and Singla DK (2013). Transplanted Induced Pluripotent Stem Cells Mitigate Oxidative Stress and Improve Cardiac Function through the Akt Cell Survival Pathway in Diabetic Cardiomyopathy. Mol Pharm. 2013 Aug 9. [Epub ahead of print] (Article).
17. Binbin Yan, Singla, R, Abdelli, LA., Singal PK., and Singla DK (2013). Regulation of PTEN/Akt Pathway Enhances Cardiomyogenesis and Attenuates Adverse Left Ventricular Remodeling Following Thymosin β4 Overexpressing Embryonic Stem Cell Transplantation in the Infarcted Heart. PLoS One. 2013 Sep 24;8(9):e75580. doi: 10.1371/journal.pone.0075580. eCollection 2013.
18. Rocher C, Singla DK (2013). SMAD-PI3K-Akt-mTOR Pathway Mediates BMP-7 polarization of Monocytes into M2 Macrophages. PLoS One. 2013 Dec 20;8(12):e84009. doi: 10.1371/journal.pone.0084009. eCollection 2013.
19. Singla DK (2014). Akt-mTOR Pathway Inhibits Apoptosis and Fibrosis in Doxorubicin-Induced Cardiotoxicity Following Embryonic Stem Cell Transplantation. Cell Transplant. 2014 Mar 3.
20. Singla DK and Abdelli, LA (2014). Embryonic Stem Cells and Released Factors Stimulate c-kit+ve/FLK-1+ve Progenitor Cells and Promote Neovascularization in Doxorubicin-induced Cardiomyopathy. Cell Transplant. 2014 Mar 3.
21. Merino H, Singla DK. Notch-1 Mediated Cardiac Protection Following Pluripotent Stem Cell Transplantation in Doxorubicin-induced. 2014 (PLos one). (Article)
22. Princess U, Singla DK (2014). BMP-7 attenuates adverse cardiac remodeling mediated through M2 macrophages in prediabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H762-72. doi: 10.1152/ajpheart.00367.2014. Epub 2014 Jul 3.
23. Reetu Singla, Jing Wang, Singla DK (2014). Notch1 Enhances THP-1 Cell into M2 Macrophage Differentiation. Am J Physiol Heart Circ Physiol. 2014 Dec 1;307(11):H1634-42. doi: 10.1152/ajpheart.00896.2013. Epub 2014 Sep 26.

For more publication information, please visit Pubmed.

(Note: Dinender Kumar Singla as Singla is a new added last name)