Cardiovascular disease is the leading cause of death in the United States and throughout the world. Dr. Gupta’s laboratory focuses on understanding the molecular mechanism of cardiomyopathy, metabolic disease, and heart failure. The long-term goal of the research is to identify the biochemical pathways altered during disease conditions to develop new drug targets for treating cardiovascular and metabolic diseases.

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Current Lab Interests

  • Role of molecular chaperones in protein homeostasis and protein aggregate disease
  • Regulation of mitochondrial function and cellular bioenergetics during health and disease
  • Small molecule and epigenetic-based therapy for metabolic diseases
  • Understanding the role of HIV-1 and antiretroviral drugs in the development of cardiomyopathy
  • Development of small rodent models for diabetics, obesity, aging, and Alzheimer’s disease and testing pharmacological drugs to treat these metabolic and protein aggregate disease

Selected Publications

  1. Randhawa PK, Rajakumar A, Futuro de Lima IB, Gupta MK. Eugenol attenuates ischemia-mediated oxidative stress in cardiomyocytes via acetylation of histone at H3K27. Free Radic Biol Med. 2023 Jan;194:326-336.
  2. Gupta MK, Randhawa PK, Masternak MM. Role of BAG5 in Protein Quality Control: Double-Edged Sword? Front Aging. 2022;3:844168.
  3. Rabbani MY, Rappaport J, Gupta MK. Activation of Immune System May Cause Pathophysiological Changes in the Myocardium of SARS-CoV-2 Infected Monkey Model. Cells. 2022 Feb 10;11(4).
  4. Kashyap S, Mukker A, Gupta D, Datta PK, Rappaport J, Jacobson JM, Ebert SN, Gupta MK. Antiretroviral Drugs Regulate Epigenetic Modification of Cardiac Cells Through Modulation of H3K9 and H3K27 Acetylation. Front Cardiovasc Med. 2021;8:634774.
  5. Randhawa PK, Gupta MK. Melatonin as a protective agent in cardiac ischemia-reperfusion injury: Vision/Illusion. Eur J Pharmacol. 2020 Oct 15;885: 173506.
  6. Gupta MK, McLendon PM, Gulick J, James J, Khalili K, Robbins J. UBC9-Mediated Sumoylation Favorably Impacts Cardiac Function in Compromised Hearts. Circ Res. 2016 Jun 10;118(12):1894-905.
  7. Gupta MK, Gulick J, James J, Osinska H, Lorenz JN, Robbins J. Functional dissection of myosin binding protein C phosphorylation. J Mol Cell Cardiol.2013 Nov;64:39-50.

Recent Publications (PubMed)

No information specified.