News of Note

Dr. Alex Cole has been awarded an R21 grant for his project entitled, “BACTERIAL VAGINOSIS INDUCES MATRIX METALLOPROTEINASES THAT ENHANCE HIV INFECTION IN WOMEN.”

Debopam Chakrabarti and his collaborator’s publication is on the cover of February Issue of ACS Infectious Diseases. This cover shows a novel antiplasmodial agent attacking malaria parasites in infected red blood cells. This new compound was re-engineered from the indole alkaloid yohimbine using a ring distortion chemical synthesis reported by Huigens, Chakrabarti and co-workers”.

Sean Moore’s research group reported the mechanistic insight of translational frameshifting as a result of ribosomes colliding in the Proceedings of the National Academy of Sciences. The figure shows that stalled ribosomes have higher E-site occupancy in the absence of ribosomal protein bL9.

Saleh Naser’s research has been highlighted on the cover of December 2019 issue of Microorganisms. The study clearly associated Mycobacterium avium subspecies paratuberculosis with osteoporosis in autoimmune disease patients, including rheumatoid arthritis, with key SNPs in the TNF receptor superfamily gene.

Recent Division Publications

Cherne MD, Cole AL, Newberry L, Schmidt-Owens M, Deichen M, Cole AM. Matrix Metalloproteinases Expressed in Response to Bacterial Vaginosis Disrupt the Endocervical Epithelium, Increasing Transmigration of HIV. Infect Immun. 2020 Mar 23;88(4). pii: e00041-20. doi: 10.1128/IAI.00041-20.

Paciaroni NG, Perry DL 2nd, Norwood VM 4th, Murillo-Solano C, Collins J, Tenneti S, Chakrabarti D*, Huigens RW 3rd*. Re-Engineering of Yohimbine’s Biological Activity through Ring Distortion: Identification and Structure-Activity Relationships of a New Class of Antiplasmodial Agents. ACS Infect Dis. 2020 Jan 16. doi: 10.1021/acsinfecdis.9b00380.

Arshadi AK, Salem M, Collin, J, Yuan JD, Chakrabarti D. DeepMalaria: Artificial Intelligence Driven Discovery of Potent Antiplasmodials. Front. Pharmacol. 15 January 2020. doi: 10.3389/fphar. 2019.01526.

Keewan E, Naser SA. The Role of Notch Signaling in Macrophages during Inflammation and Infection: Implication in Rheumatoid Arthritis? Cells. 2020 Jan 2;9(1). pii: E111. doi: 10.3390/cells9010111.

Naser A, Odeh AK, Sharp RC, Qasem A, Beg S, Naser SA. Polymorphisms in TNF Receptor Superfamily 1B (TNFRSF1B:rs3397) are Linked to Mycobacterium avium paratuberculosis Infection and Osteoporosis in Rheumatoid Arthritis. Microorganisms. 2019 Dec 4;7(12). pii: E646. doi: 10.3390/microorganisms7120646.

Cherubin P, Fidler D, Quiñones B, Teter K. Bimodal Response to Shiga Toxin 2 Subtypes Results from Relatively Weak Binding to the Target Cell. Infect Immun. 2019 Nov 18;87(12). pii: e00428-19. doi: 10.1128/IAI.00428-19.

Smith AM, Costello MS, Kettring AH, Wingo RJ, Moore SD. Ribosome collisions alter frameshifting at translational reprogramming motifs in bacterial mRNAs. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21769-21779. doi: 10.1073/pnas.1910613116.

Miller-Dickson MD, Meszaros VA, Almagro-Moreno S, Brandon Ogbunugafor C. Hepatitis C virus modelled as an indirectly transmitted infection highlights the centrality of injection drug equipment in disease dynamics. J R Soc Interface. 2019 Sep 27;16(158):20190334. doi: 10.1098/rsif.2019.0334.

Prosperi M, Salemi M, Azarian T, Milicchio F, Johnson JA, Oliva M. Unexpected Predictors of Antibiotic Resistance in Housekeeping Genes of Staphylococcus Aureus. ACM BCB. 2019 Sep;2019:259-268. doi: 10.1145/3307339.3342138.

Guyette J, Evangelista B, Tatulian SA, Teter K. Stability and Conformational Resilience of Protein Disulfide Isomerase. Biochemistry. 2019 Aug 27;58(34):3572-3584. doi: 10.1021/acs.biochem.9b00405.