Publications

  1. “Kinetic and Stereochemical Effect of a Fluorine Substituent on the Cope and the Homodienyl [1,5] Hydrogen Shift Rearrangements,” Dolbier, Jr., W. R.; Alty, A. C.; Phanstiel IV, O. J. Am. Chem. Soc. 1987, 109, 3046-3050.
  2. “The Non-Steric Origin of Specific Disrotatory Ring Openings in Solvolyses of Cyclopropyl Derivatives. The 2-Fluorocyclopropyl Bromide system,” Dolbier, Jr., W. R.; Phanstiel IV, O. Tetrahedron Letters 1988, 29, No. 1, 53-56.
  3. “Fluorine- versus Methyl-Substituent Effects in the 6-methylenebicyclo[3.2.0]hept-2-ene -5-methylene-bicyclo-[2.2.1]hept-2-ene Thermal Rearrangement,” Dolbier, Jr., W. R.; Phanstiel IV, O. J. Am. Chem. Soc. 1989, 111, 4907-4911.
  4. “The In Situ Generation and Trapping of Some Fluorine-Substituted Ketenes,” Dolbier, Jr., W. R.; Lee, S. K.; Phanstiel IV, O. Tetrahedron 1991, 47, 2065-2072.
  5. “The Total Synthesis of Nannochelin: A Novel Cinnamoyl Hydroxamate-Containing Siderophore,” Bergeron, R. J.; Phanstiel IV, O. J. Org. Chem. 1992, 57, 7140-7143.
  6. “Reactive Processing of Blends of Functionalized Poly-(2,6-dimethyl-1,4 phenylene oxide) and Poly(butylene-terephthalate),” Hobbs, S. Y.; Stanley, T. J. ; Phanstiel IV, O. Polymer Preprints 1992, 33, No. 2, 614.
  7. “The Total Synthesis of Hypusine and its (2S,9S) Diastereomer,” Bergeron, R. J. ; Xia, M. X. B.; Phanstiel IV, O. J. Org. Chem. 1993, 58, 6804-6806.
  8. “Macromolecular Self-Assembly of Diketopiperazine Tetrapeptides, ” Bergeron, R. J.; Phanstiel IV, O. ; Yao, G. W.; Milstein, S.; Weimar, W. R. J. Am. Chem. Soc. 1994, 116, 8479-8484.
  9. “A Versatile Synthesis of Desferrioxamine,” Bergeron, R. J.; McManis, J. S. ; Phanstiel IV, O.; Vinson, J. R. J. Org. Chem. 1995, 60, 109-114.
  10. “An Investigation of the Impact of Molecular Geometry upon Microcapsule Self-Assembly,” Bergeron, R. J.; Yao, G. W.; Erdos, G.; Milstein, S.; Gao, F.; Weimar, W. R.; Phanstiel IV, O. J. Am. Chem. Soc. 1995, 117, 6658-6665.
  11. “Development of a Hypusine Reagent for Peptide Synthesis,” Bergeron, R. J.; Ludin, C.; Muller, R.; Smith, R. E.; Phanstiel IV, O. J. Org. Chem. 1997, 62, 3285-3290.
  12. “A Comparison of Structure Activity Relationships between Spermidine and Spermine Analogue Antineoplastics,” with Bergeron, R. J.; Feng, Y.; Weimar, W. R.; McManis, J. S.; Dimova, H.; Porter, C.; Raisler, B.; Phanstiel IV, O. J. Med. Chem. 1997, 40, No. 10, 1475-1494.
  13. “The Influence of Molecular Conformation Upon the Self-Assembly of Cyclohexane Diamide Diacids,” Bergeron, R.J.; Yao, G. W.; Erdos, G. W.; Milstein, S.; Gao, F.; Rocca, J.; Weimar, W. R.; Price, H. L.; Phanstiel IV, O. Bioorg. Med. Chem. 1997, 5 (11), 2049-2061.
  14. “An Improved Synthesis of O-Benzoyl Protected Hydroxamates” Wang, Q. X.*; King, J.+; Phanstiel IV, O. J. Org. Chem. 1997, 62, 8104-8108.
  15. “Total Synthesis of Acinetoferrin” Wang, Q. X.*; Phanstiel IV, O. J. Org. Chem. 1998, 63, 1491-1495.
  16. “Synthesis of Exotic Soaps in the Chemistry Laboratory,” Phanstiel IV, O. ; Dueno, E.+; Wang, Q. X.* J. Chem. Ed. 1998, 75, No. 5, 612-614.
  17. “Supramolecular Construction Using Diamide Diacids Containing Aromatic Amino Acids,” Phanstiel IV, O.; Price, H. L.; Torres, D.; Richardson, M.; Seconi, D.* Florida Scientist 1998, 61, Suppl. 1, 36.
  18. “Vectored Antineoplastics Predicated Upon Polyamine-DNA Intercalator Conjugates,” Phanstiel IV, O.; Majmundar-Shah, S.*; Wang, L.*; Price, H. L. Florida Scientist 1998, 61, Suppl. 1, 37.
  19. “Synthesis of Secondary Amines via N-(Benzoyloxy)amines and Organoboranes” Phanstiel, IV, O.; Wang, Q. X.*; Powell, D. H.; Ospina, M. P.; Leeson, B. A.+ J. Org. Chem. 1999, 64, 803-806.
  20. “Synthesis of N-Hydroxy)amide and N-(Hydroxy)thioamide-Containing Peptides,” Wang, L.*; Phanstiel IV, O. J. Org. Chem. 2000, 65, 1442-1447.
  21. “The Effect of Polyamine Homologation on the Transport and Cytotoxicity Properties of Polyamine-DNA Intercalator Conjugates” Phanstiel IV, O.; Price, H.L.; Wang, L.*; Juusola, J.; Kline, M.; Shah, S.M.* J. Org. Chem. 2000, 65, 5590-5599.
  22. “Mechanism of Crystalline Dicarboxamide Microsphere Self-Assembly Probed by In Situ Raman Microscopy and Raman Imaging,” Matsui, H.; Gologan, B.; Schaffer, H.; Adar, F.; Seconi, D.; Phanstiel IV, O. Langmuir, 2000, 16, 3148-3153.
  23. “Nanoconstruction Using Proton-Induced Phase Transitions: Molecular Self-Recognition by Diamide Diacids in Aqueous Environments” Phanstiel IV, O.; Erdos, G. W.; Lachicotte, R.J.; Torres, D.; Richardson, M.; Matsui, H.; Schaffer, H.; Adar, F.; Seconi, D.* Chem. Mater. 2001, 13, 264-272.
  24. “The Influence of Polyamine Architecture on the Transport and Topoisomerase II Inhibitory Properties of Polyamine DNA-Intercalator Conjugates,” Wang, L.*; Price, H.L.; Juusola, J.; Kline, M.; Phanstiel, IV, O. J. Med. Chem. 2001, 44, 3682-3691.
  25. “Synthesis and Biological Evaluation of New Citrate-Based Siderophores as Potential Probes for the Mechanism of Iron Uptake in Mycobacteria” Guo, H.*; Naser, S.A.; Ghobrial, G.; Phanstiel, IV, O. J. Med. Chem. 2002, 45, 2056-2063.
  26. “Molecular modeling of the 1,1-Cyclopropane and 1,1-Cyclobutane-dicarboxamide Systems: Insights into the Self-Assembly of Diamide Diacids in Water” Breitbeil, F.; Phanstiel, IV, O. Structural Chemistry, 2002, 13, 443-453.
  27. “Synthesis and Characterization of N1-(4-toluenesulfonyl)-N1-(9-anthracenemethyl)-triamines” Wang, C.; Abboud, K.A.; Phanstiel IV, O. J. Org. Chem. 2002, 67, 7865-7868.
  28. “N-(Benzoyloxyamines): an investigation of their thermal stability, synthesis and incorporation into novel peptide constructs,” Nemchik, A.+; Badescu, V.*; Phanstiel IV, O. Tetrahedron 2003, 59, No. 24, 4315 – 4325.
  29. “Synthesis and Biological Evaluation of N1-(anthracen-9-ylmethyl)triamines as Molecular Recognition Elements for the Polyamine Transporter,” Wang, C.; Delcros, J-G.; Biggerstaff, J.; Phanstiel IV, O. J. Med. Chem. 2003, 46, 2663-2671.
  30. “Molecular Requirements for Targeting the Polyamine Transport System: Synthesis and Biological Evaluation of Polyamine-Anthracene Conjugates,” Wang, C.; Delcros, J-G.; Biggerstaff, J.; Phanstiel IV, O. J. Med. Chem. 2003, 46, 2672-2682.
  31. “Defining the Molecular Requirements for the Selective Delivery of Polyamine-Conjugates into Cells Containing Active Polyamine Transporters,” Wang, C.; Delcros, J-G.; Cannon, L.+; Konate, F.*; Carias, H.+; Biggerstaff, J.; Gardner, R.A.; Phanstiel IV, O. J. Med. Chem. 2003, 46, 5129-5138.
  32. “Total Synthesis of Petrobactin and Its Homologues as Potential Growth Stimuli for Marinobacter hydrocarbonoclasticus, an oil-degrading bacteria.” Gardner, R.A.; Kinkade, R.+; Wang, C. ; Phanstiel IV, O. J. Org. Chem. 2004, 69, 3530-3537.
  33. “Synthesis and Biological Evaluation of new Acinetoferrin Homologues for use as Iron Transport Probes in Mycobacteria,” Gardner, R.A.; Ghobrial, G.; Naser, S.A.; Phanstiel IV, O. J. Med. Chem. 2004, 47, 4933-4940.
  34. “N1-Substituent Effects in the Selective Delivery of Polyamine-Conjugates into Cells Containing Active Polyamine Transporters” Gardner, R.A.; Delcros, J-G.; Konate, F.*; Breitbeil III, F.; Martin, B.; Sigman, M.; Huang, M.; Phanstiel IV, O. J. Med. Chem. 2004, 47, 6055-6069.
  35. “Synthesis and Biological Evaluation of Dihydromotuporamine Derivatives in Cells Containing Active Polyamine Transporters” Kaur, N,; Delcros, J-G.; Martin, B.; Phanstiel, IV, O. J. Med. Chem. 2005, 48, 3832-3839.
  36. “Modeling the Preferred Shapes of Polyamine Transporter Ligands and Dihydromotuporamine-C Mimics: Shovel versus Hoe,” Breitbeil III, F. Kaur, N.; Delcros, J-G.; Martin,B.; Abboud, K.A.; Phanstiel, IV, O. J. Med. Chem. 2006, 49, 2407-2416.
  37. Comparative Studies of Anthraquinone- and Anthracene-Tetraamines as Blockers of N-Methyl-D-aspartate Receptors. Jin, L.; Sugiyama, H.; Takigawa, M.; Katagiri, D.; Tomitori, H.; Nishimura, K.; Kaur, N.; Phanstiel, IV, O.; Kitajima, M.; Takayama, H.; Okawara, T.; Williams, K.; Kashiwagi, K.; Igarashi, K. JPET 2007, 320, 47-55.
  38. Synthesis and Transfection Efficiencies of new Lipophilic Polyamines. Gardner, R.A.; Belting, M.; Svensson, K.; Phanstiel, IV, O. J. Med. Chem. 2007, 50, 308-318.
  39. Synthesis and Bioevaluation of the N-(Arylalkyl)-Homospermidine Conjugates. Songqiang Xie, Pengfei Cheng, Guangchao Liu, Yuangfang Ma, Jin Zhao, Mounir Chehtane, Annette R. Khaled, Otto Phanstiel IV and Chaojie Wang. Bioorganic & Medicinal Chemistry Letters 2007, 17, 4471-4475.
  40. Structure-activity Investigations of Polyamine-anthracene Conjugates and their Uptake via the Polyamine Transporter. Phanstiel, IV, O.; Kaur, N.; Delcros, J-G. Amino Acids, 2007, 33, No. 2, 305-313.
  41. Lipopolyamine Treatment Increases the Efficacy of intoxication with Saporin and an Anti-cancer Saporin Conjugate. Geden, S.; Gardner, R.; Fabbrini, S.M.; Ohashi, M.; Phanstiel IV, O. Teter, K. FEBS Journal, 2007, 274, No. 18, 4825-4836.
  42. Utilization of Fe3+ -Acinetoferrin Analogues as an iron source by Mycobacterium tuberculosis. Rodriguez, G. M.; Gardner, R. A.; Kaur, N.; Phanstiel IV, O. Biometals 2008, 21, 93-103.
  43. A Drosophila model to identify polyamine-drug conjugates that target the polyamine transporter in an intact epithelium, Chung Tsen†§, Mark Iltis†§, Navneet Kaur†, Cynthia Bayer§, Jean-Guy Delcros‡, Laurence von Kalm§* and Otto Phanstiel IV†* J. Med Chem., 2008, 51, 324–330.
  44. A Comparison of Chloroambucil- and Xylene-containing polyamines leads to improved ligands for accessing the polyamine transporter. Navneet Kaur, Jean-Guy Delcros, and Otto Phanstiel IV. J. Med. Chem. 2008, 51, 1393-1401.
  45. A Delineation of Diketopiperazine self-assembly processes: Understanding the molecular events involved in Ne-(fumaroyl) diketopiperazine of L-Lys (FDKP) interactions. Navneet Kaur, Bo Zhou, Fred Breitbeil,  Katherine Hardy, Kelly S. Kraft, Iva Trantcheva and Otto Phanstiel IV, Molecular Pharmaceutics, 2008, 5, No. 2, 294-315.
  46. Designing the Polyamine Pharmacophore: Influence of N-substituents on the transport behavior of polyamine conjugates, Kaur, N.; Delcros, J-G.; Archer, J.; Weagraff, N.Z.; Martin, B.; Phanstiel IV, O. J. Med. Chem. 2008, 51, 2551-2560.
  47. Chemoselective N-acylation via Condensations of N-(Benzoyloxy)amines and a-Keto-phosphonic acids under Aqueous Conditions. Jasbir Singh Arora, Navneet Kaur and Otto Phanstiel IV, J. Org. Chem. 2008, 73, 6182-6186.
  48. Synthesis and evaluation of unsymmetrical polyamine derivatives as antitumor agents. Wang, J.; Xie, S.; Li, Y.; Guo, Y.; Ma, Y.; Zhao, J.; Phanstiel IV, O.; Wang, C. Bioorg. Med. Chem. 2008, 16, 7005-7012.
  49. A Putrescine-anthracene conjugate: a paradigm for selective drug delivery. Andrew J. Palmer, Radiah A. Ghani, Navneet Kaur, Otto Phanstiel and Heather M. Wallace. Biochem. J. 2009, 424, 431-438.
  50. Anthracene Polyamine Conjugates, Potent anticancer agents targeted to cancer cells via the Polyamine Transport System. Ghani, R.A.; Palmer, A.J.; Kaur, N.; Phanstiel, O.; Wallace, H.M. Basic & Clinical Pharmacology & Toxicology 2009, 105, 117-118.
  51. The polyamine transport system: A means of selective delivery of potentially toxic agents to cancer cells? Ghani, R.A.; Palmer, A.J.; Kaur, N.; Phanstiel, O.; Wallace, H.M. Toxicology 2009, 262, 13-13.
  52. Polyamine Transport as a Target for Pneumocystis Pneumonia Therapy. Chung-Ping Liao, Otto Phanstiel IV, Mark E. Lasbury, Chen Zhang, Shoujin Shao, Pamela J. Durant, Bi-Hua Cheng, and Chao-Hung Lee, Antimicrobial Agents and Chemotherapy 2009, 53, No. 12, 5259-5264.
  53. Delivering anti-cancer agents to human leukaemic cells via polyamine transport system Heather M. Wallace, Radiah A. Ghani, Andrew J. Palmer, Navneet Kaur, and Otto Phanstiel, S55, 11th International Congress on Amino Acids, Peptides and Proteins, Aug 3-7, 2009. Amino Acids 2009, 37 (Suppl. 1):S1-S127.
  54. Anthracene polyamine conjugates induce cell death in human leukaemic cells. Ghani, R.A.; Kaur, N.; Phanstiel, O.; Wallace, H.M. Toxicology 2010, 278, 373-373 (special issue).
  55. Caenorhabditis elegans P5B-type ATPase CATP-5 operates in polyamine transport and is crucial for norspermidine-mediated suppression of RNA interference. Heinick, A. Urban, K.; Roth, S.; Spies, D.; Nunes, F.; Phanstiel IV, O.; Liebau, E. Lüersen, K. FASEB J 2010, 24, 206-217.
  56. Polyamine-anthracene conjugates show promise in delivery of cytotoxic agents to human solid tumor cells. Xiao, X.; Phanstiel, O.; Wallace, H.M. Toxicology, 2011, 290, 114-115.
  57. Design of Polyamine Transport Inhibitors as Therapeutics. Otto Phanstiel IV; Jennifer J. Archer, in Polyamine Drug Discovery, P. Woster and R.A. Casero, eds., RSC Publishing, 2012. 162-187. ISBN 9781849731904.
  58. Chemoselective Amide Formation UsingO-(4-Nitrophenyl)–hydroxylamines and Pyruvic Acid Derivatives. Sonali Kumar,Rashi Sharma, Megan Garcia, Joseph Kamel, Caroline McCarthy, Aaron Muth, and Otto Phanstiel, IV.  J. Org. Chem. 2012, 77, 10835–10845.
  59. Ant 4,4, a polyamine-anthracene conjugate, induces cell death and recovery in human promyelogenous leukemia cells (HL-60). Traquete, R.; Ghani, R.A.; Phanstiel, O.; Wallace, H.M. Amino Acids 2013, 44, 1193-1203.
  60. Anthracene-polyamine conjugates inhibitin vitroproliferation of intraerythrocytic Plasmodium falciparum parasites. Niemand, J.; Burger, P.; Verlinden, B.; Reader, J.; Joubert, A.; Kaiser, A.; Louw, A.I.; Kirk, K.; Phanstiel IV, O.; Birkholtz, L-M. Antimicrobial Agents and Chemotherapy. 2013, 57, 2874-2877.
  61. Putrescine importer PlaP contributes to swarming motility and urolithelial cell invasion in Proteus mirabilis. Kurihara, S.; Sakai, Y.; Suzuki, H.; Muth, A.; Phanstiel, O.; Rather, P.N. J. Biol. Chem. 2013, 288, 15668-15676.
  62. Development of Flavonoid-based Inverse Agonists of the Key signaling receptor US28 of Human Cytomegalovirus. Ana Kralj, Mai-Thao Nguyen, Nuska Tschammer, Nicolette Ocampo, Quinto Gesiotto, Markus R. Heinrich, and Otto Phanstiel, IV. J. Med. Chem. 2013, 56, 5019-5032.
  63. Development of Polyamine Transport Ligands with Improved Metabolic Stability and Selectivity against Specific Human Cancers. Aaron Muth, Joseph Kamel, Navneet Kaur, Allyson C. Shicora, Iraimoudi S. Ayene, Susan K. Gilmour, and Otto Phanstiel IV. J. Med. Chem. 2013, 56, 5819-5828.
  64. Polyamine transport inhibitors: Design, Synthesis and Combination therapies with Difluoromethylornithine. Aaron Muth, Jennifer Archer, Nicolette Ocampo, Meenu Madan, Luis Rodriguez, and Otto Phanstiel IV. J. Med. Chem. 2014, 57, 348-363.
  65. Synthesis and Biological Evaluation of Anti-metastatic Agents Predicated upon Dihydromotuporamine C and its Carbocyclic Derivatives. Aaron Muth, Veethika Pandey, Navneet Kaur, Melissa Wason, Cheryl Baker, Xianlin Han, Teresa R. Johnson, Deborah A. Altomare, and Otto Phanstiel IV. J. Med. Chem. 2014, 57, 4023-4034.
  66. Inhibition of Polyamine Uptake Potentiates the Anti-Proliferative Effect of Polyamine Synthesis Inhibition and Preserves the Contractile Phenotype of Vascular Smooth Muscle Cells Grossi, M.; Phanstiel, O.; Rippe, K.; Sward, K.; Alajbegovic, A.; Albinsson, S.; Forte, A.; Persson, L.; Hellstrand, P.; Nilsson, B-O. J. Cell. Physiol. 2015, 9999, 1–9.
  67. Synthesis and Bioevaluation of Substituted Chalcones, Coumaranones and other Flavonoids as anti-HIV agents. Amy L. Cole, Sandra Hossain, Alex M. Cole, and Otto Phanstiel IV. Bioorg. Med. Chem. 2016, 24, 2768-2776.
  68. ATP13A3 and Caveolin-1 as Potential Biomarkers for Difluoromethylornithine-based therapies in Pancreatic Cancers. Meenu Madan, Arjun Patel, Kristen Skruber, Dirk Geerts, Deborah A. Altomare, and Otto Phanstiel IV. Am J. Cancer Res 2016, 6, 1231-1252.
  69. Motuporamine derivatives as antimicrobial agents and antibiotic enhancers against resistant Gram-negative bacteria. Diane Borselli, Marine Blanchet, Jean-Michel Bolla, Aaron Muth, Kristen Skruber, Otto Phanstiel IV and Jean Michel Brunel. ChemBioChem. 2017, 18, 276-283.
  70. A Novel Polyamine Blockade Therapy Activates an Anti-Tumor Immune Response. Alexander, E.; Minton, A.; Peters, M.; Phanstiel, O.; Gilmour, S. Oncotarget 2017, 8, 84140-84152.
  71. Synthesis and Bioevaluation of Macrocycle- Polyamine Conjugates as Cell Migration Inhibitors. Skruber, K.; Chaplin, K.J.; Phanstiel, O. J. Med. Chem. 2017, 60, 8606−8619. doi: 10.1021/acs.jmedchem.7b01222
  72. Evaluation of Polyamine Transport Inhibitors in a Drosophila Epithelial Model Suggests the Existence of Multiple Transport Systems. Minpei Wang, Otto Phanstiel IV, Laurence von Kalm. Med. Sci. 2017, 5, 27. doi:10.3390/medsci5040027
  73. Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers. Chelsea Massaro, Jenna Thomas, and Otto Phanstiel IV. Med Sci. 2017, 5, 32. doi:10.3390/medsci5040032
  74. A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors. Molly C. Peters, Allyson Minton, Otto Phanstiel IV, and Susan K. Gilmour. Med. Sci. 2018, 6, 3. doi:10.3390/medsci6010003
  75. Difluoromethylornithine Combined with a Polyamine Transport Inhibitor is Effective against Gemcitabine Resistant Pancreatic Cancer. Gitto, Sarah; Pandey, Veethika; Oyer, Jeremiah; Copik, Alicja; Hogan, Frederick; Phanstiel, Otto; Altomare, Deborah. Mol Pharmaceutics 2018, 15, 369-376.
  76. Targeting polyamine transport in Trypanosoma cruzi. Chantal Reigada, Otto Phanstiel IV, Mariana R. Miranda, Claudio A. Pereira. Eur. J. Med. Chem. 2018, 147, 1-6.
  77. An Overview of Polyamine Metabolism in Pancreatic Ductal Adenocarcinoma. Otto Phanstiel IV. Int. J. Cancer 2018, 142, 1968-1976. doi:10.1002/ijc.31155
  78. Antibiotic Adjuvants: Make Antibiotics Great Again! Hana Douafer, Véronique Andrieu, Otto Phanstiel IV, Jean Michel Brunel. J. Med. Chem. 2019, 62, 8665-8681. https://doi.org/10.1021/acs.jmedchem.8b01781
  79. FP028: Calcium Sensor Receptor Modulation is a Mechanism for the Medicinal Effects of Plant Derived Polyphenols. Edward Ross, Alexander Bosak, Dwight Towler, Timothy Gilbertson, Bradley Willenberg, Alicia Willenberg, Naima Dahir, Otto Phanstiel. Nephrology Dialysis Transplantation, 2019, 34, Suppl.1, June 13, 2019, https://doi.org/10.1093/ndt/gfz106.FP028
  80. Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing. Chantal Reigada, Melisa Sayé, Otto Phanstiel IV, Edward Valera-Vera, Mariana Reneé Miranda, Claudio A. Pereira. Front. Med. 2019, 6, No. 256, Nov 8, 2019 https://doi.org/10.3389/fmed.2019.00256
  81. Serendipitous Discovery of Leucine and Methionine Depletion Agents during the Search for Polyamine Transport Inhibitors. Chelsea Massaro, Jenna Thomas, Houssine Ikhlef, Sharifa Dinara, Sara Cronk, Holly Moots, and Otto Phanstiel IV, J. Med. Chem. 2020, 63, 2814-2832.  https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.9b00568
  82. Polyamine Blocking Therapy Decreases Survival of Tumor-Infiltrating Immunosuppressive Myeloid Cells and Enhances the Anti-Tumor Efficacy of PD-1 Blockade. Susan K. Gilmour, Eric T Alexander, Kelsey Mariner, Julia Donnelly, and Otto Phanstiel. Molecular Cancer Therapeutics, 2020, 19, 2012-2022. https://mct.aacrjournals.org/content/19/10/2012
  83. The involvement of polyamine uptake and synthesis pathways in the proliferation of neonatal astrocytes. Christian J. Malpica-Nieves, David E. Rivera-Aponte, Flavia A.  Tejeda-Bayron, Angel M. Mayor, Otto Phanstiel, Rüdiger W. Veh, Misty J.  Eaton, Serguei N. Skatchkov. Amino Acids 2020, 52, 1169-1180. https://link.springer.com/article/10.1007/s00726-020-02881-w
  84. Harnessing the polyamine transport system to treat BRAF inhibitor-resistant melanoma. Eric T. Alexander, Olivia El Naggar, Erin Fahey, Kelsey Mariner, Julia Donnelly, Katelyn Wolfgang, Otto Phanstiel, and Susan K. Gilmour. Cancer Biology & Therapy 2021, 1-13. https://doi.org/10.1080/15384047.2021.1883185
  85. The discovery of indolone GW5074 during a comprehensive search for non-polyamine-based polyamine transport inhibitors. Aiste Dobrovolskate, Meenu Madan, Veethika Pandey, Deborah A. Altomare, Otto Phanstiel. Int. J. Biochem. Cell Biol. 2021, 138, 106038. https://doi.org/10.1016/j.biocel.2021.106038
  86. Uptake of Biotinylated Spermine in Astrocytes: Effect of Cx43 siRNA, HIV‐Tat Protein and Polyamine Transport Inhibitor on Polyamine Uptake. Christian J. Malpica‐Nieves, Yomarie Rivera, David E. Rivera‐Aponte, Otto Phanstiel, Rüdiger W. Veh, Misty J. Eaton, and Serguei N. Skatchkov. Biomolecules 2021, 11, 1187. https://doi.org/10.3390/biom11081187
  87. Development of a redox sensitive spermine prodrug for the potential treatment of Snyder Robinson Syndrome. Mukund P. Tantak, Vandana Sekhar, Xianzun Tao, R. Grace Zhai, and Otto Phanstiel IV. J. Med. Chem. 2021, 64, 15593-15607. https://pubs.acs.org/doi/full/10.1021/acs.medchem.1c00419
  88. Sai Preethi Nakkina, Sarah B. Gitto, Veethika Pandey, Jignesh G. Parikh, Dirk Geerts, Hans Carlo Maurer, Ken P. Olive, Otto Phanstiel IV, and Deborah A. Altomare. Differential expression of polyamine pathways in human pancreatic tumor progression and effects of polyamine blockade on tumor microenvironment, Cancers (Basel) 2021, 13, 6391. https://doi.org/10.3390/cancers13246391
  89. Sai Preethi Nakkina, Sarah B. Gitto, Jordan M. Beardsley, Veethika Pandey, Michael Rohr, Jignesh G. Parikh, Otto Phanstiel IV, and Deborah A. Altomare. DFMO improves survival and increases immune cell infiltration in association with MYC downregulation in the pancreatic tumor microenvironment. Int J Mol Sci. 2021, 22, 13175. https://doi.org/10.3390/ijms222413175
  90. Development of polyamine lassos as polyamine transport inhibitors. Aiste Dobrovolskaite, Richard Andrew Gardner, Jean-Guy Delcros, and Otto Phanstiel IV. ACS Med Chem Lett, 2022, 13, 319-326. https://doi.org/10.1021/acsmedchemlett.1c00557
  91. ATP13A3 facilitates polyamine transport in human pancreatic cancer cells. Vandana Sekhar, Thomas Andl, and Otto Phanstiel IV. Scientific Reports, 2022, 12, 4045. https://doi.org/10.1038/s41598-022-07712-4
  92. Pancreatic Ductal Adenocarcinoma (PDAC) circulating tumor cells influence myeloid cell differentiation to support their survival and immunoresistance in portal vein circulation. Juan Pablo Arnoletti, Joseph Reza , Armando Rosales, Alberto Monreal, Na’im Fanaian, Suzanne Whisner, Milan Srivastava, Julia Rivera-Otero, Gongxin Yu, Otto Phanstiel IV, Deborah A Altomare, Quang Tran, Sally A Litherland. PLOS One 2022, 17, e0265725. https://doi.org/10.1371/journal.pone.0265725
  93. Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci. Moses B. Ayoola, Leslie A. Shack, Jung Hwa lee, Juhyeon Lim, Hyungjin Eoh, Edwin Swiatlo, Otto Phanstiel IV, Bindu, Nanduri. Scientific Reports 2022, 12, 11804. https://doi.org/10.1038/s41598-022-16007-7