Accomplishments

Dr. Phanstiel has filed and been awarded numerous patents for his research efforts.

  1. “Copolymer-Containing Compositions from Substituted Triazine-Capped Polyphenylene Ethers,” with S. B. Brown, U.S. Patent # 5,010,144 (4/23/91). European Patent #91108309.5 (7/17/91).
  2. “Substituted chlorotriazines useful for reactive capping of polyphenylene ethers,” with S.B. Brown, U.S. Patent # 5,159,075 (10/27/92), European Patent #91108306.1(7/17/91).
  3. “Substituted Triazine-capped Polyphenylene Ethers,” with S.B. Brown, U.S. Patent # 5,210,191 (5/11/93), European Patent #91108308.7 (7/17/91).
  4. “Ortho Ester-Capped Polyphenylene Ethers and Copolymers prepared therefrom,” with F. F. Khouri, S.B. Brown, and J.T. Jackman, U.S. Patent # 5,132,373, (7/21/92). European Patent # 91112495.6 (9/18/91).
  5. “Ortho Ester-Substituted chlorotriazines as capping agents for polyphenylene ethers,” with F. F. Khouri and J.T. Jackman, U.S. Patent # 5,142,049, (8/25/92). European Patent # 91112490.7 (9/18/91).
  6. “Substituted Triazine-Capped Polyphenylene Ethers,” with S. B. Brown, U.S. Patent #5,089,567 (2/18/92).
  7. “Ortho Ester-Capped Polyphenylene Ethers and Copolymers prepared therefrom,” with F. F. Khouri, U.S. Patent # 5,162,448 (11/10/92).
  8. “Compounds and Method for Enhancing the Efficacy of Anti-Cancer Drugs” U.S. Patent 7,001,925 (2/21/2006)
  9. “Polyamine conjugates as Selective NMDA inhibitors and anti-cancer drugs” U.S. Patent: 7,728,040 (6/1/2010)
  10. “Motuporamine Mimic Agents” U.S. Patent: 7,728,041 (6/1/2010).
  11. “Diagnostic tests for inflammatory bowel diseases” U.S. Patent 7,972,807 (7/5/2011)
  12. “Lipophilic polyamines providing enhanced intracellular delivery of agents by a polyamine transport system” U.S. Patent 7,910, 363 (3/22/2011)
  13. “Polyamine Transport Inhibitors as Novel Therapeutics”, US-2012-0172449-A1, Pub Date: 07/05/2012.
  14. Methods for the synthesis of activated ethyl-fumarates and their use as intermediates. U.S. Patent Application 13/834,106 (3/15/2013); US20130289278 A1.
  15. “Fluorescent Cytotoxic Compounds Specific for the Cellular Polyamine Transport System.” U.S. Patent 8,410,311 (4/2/2013).
  16. “Polyamine Transporter Selective Compounds as Anti-Cancer Agents.” Otto Phanstiel, U.S. Patent 8,497,398 (July 30, 2013).
  17. “Antimetastatic Agents Predicated upon Polyamine-macrocyclic conjugates”. Otto Phanstiel IV and Aaron Muth. World Patent, WO 2013148219 A1, October 3, 2013.
  18. “Polyamine Transport Selective Therapeutic Agents with Enhanced Stability.” Otto Phanstiel IV and Aaron Muth, World Patent, WO 2013148230 A1, October 3, 2013.
  19. “Fluorescent Cytotoxic Compounds Specific for the Cellular Polyamine Transport System”, Otto Phanstiel IV, U.S. Patent 2013-0337494-A1 (Dec 19, 2013).
  20. “Polyamine Transporter Selective Compounds as Anticancer agents”, Otto Phanstiel, U.S. Patent US-2014-0057989-A1 (February 27, 2014).
  21. “Flavonoid based Antiviral Targets”. Otto Phanstiel and Nuska Tschammer, World Patent WO 2014047551 A1 (March 27, 2014).
  22. Anti-metastatic agents predicated upon polyamine macrocyclic conjugates. Otto Phanstiel and Aaron Muth, U.S. Patent No. US 9,266,815 B2 (February 23, 2016).
  23. Assays and Methods for Cell Proliferation-Targeted Treatment Therapies. Otto Phanstiel, Deborah Altomare, and Laurence von Kalm. U.S. Patent US2016/0299149 A1 (Oct. 13, 2016).
  24. Polyamine Transport Selective Therapeutic Agents with Enhanced Stability. Otto Phanstiel IV and Aaron Muth, U.S. Patent US2016/0311756 A1, (Oct. 27, 2016).
  25. Flavonoid Based Antiviral Targets, Otto Phanstiel, Nuska Tschammer, U.S. Patent 9,629,822 (4/25/2017)
  26. Polyamine Transport Selective Compounds as Anti-Cancer Agents. Otto Phanstiel, US Patent 9,598,351, (3/21/2017)
  27. Motuporamine Derivatives as Antimicrobial Agents and Antibiotic Enhancers Against Resistant Gram-Negative Bacteria, Provisional patent filed 1/9/2017.
  28. Polyamine Transport Inhibitors as Novel Therapeutics, Otto Phanstiel, US Patent 9730902 B2. 8/15/2017
  29. Immunomodulatory Compounds. Susan Gilmour and Otto Phanstiel. European Patent Office App# 17877975.7-1109 PCT/US2017065305, 8/12/2017 (US201662431663) issued May 12, 2019
  30. Polyamine Transport Selective Therapeutic Agents with Enhanced Stability, Otto Phanstiel, US 9,926,260 B2. 3/27/2018
  31. Non-Polyamine based Polyamine Transport Inhibitors and their use in the treatment of human cancers, Docket # 10669-260USO, filed 8/3/2018
  32. Amino Acid Transport Inhibitors as Antiproliferative Agents, Docket # 10669-266USO, filed 8/28/2018
  1. Formation of N-Protected 3,6-Bis-(4-aminobutyl)-2,5-diketopiperazine through a cyclic alpha-N-protected aminoester intermediate. John J. Freeman, Otto Phanstiel, William Elliot Bay, and Kelly S. Kraft. U.S. Patent 10,577,331 B2, March 3, 2020.