Publications

2023

  • Lee E, Park Y, Li D, Rodriguez-Fuguet A, Wang X, Zhang WC. Antidepressant Use and Lung Cancer Risk and Survival: A Meta-analysis of Observational Studies. Cancer Res Commun. 2023;3(6):1013-25. Epub 20230612. doi: 10.1158/2767-9764.Crc-23-0003; PMCID: PMC10259481. View PDF
  • Aftab F, Rodriguez-Fuguet A, Silva L, Kobayashi IS, Sun J, Politi K, Levantini E, Zhang W, Kobayashi SS, Zhang WC. An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1. Br J Cancer. 2023. Epub 20230221. doi: 10.1038/s41416-023-02196-z. PubMed PMID: 36810913. View PDF

2022

  • Zhang WC, Skiados N, Aftab F, Moreno C, Silva L, Corbilla PJA, Asara JM, Hata AN, Slack FJ. MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state. Cancer Gene Therapy. 2022:1-17. doi: 10.1038/s41417-022-00504-y. Epub 2022 Jul 15.PMID: 35840668. View PDF
  • Talukder A, Zhang W, Li X, Hu H. A deep learning method for miRNA/isomiR target detection. Sci Rep. 2022 Jun 23;12(1):10618. doi: 10.1038/s41598-022-14890-8. PMID: 35739186; PMCID: PMC9226005. View PDF
  • Rodriguez-Fuguet A, Zhang W-C. Targeting EGFR-steered cancer via erasing a circular RNA. ExRNA. 2022. View PDF

2021

  • Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI. METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation. Mol Cell. 2021 Jul 29:S1097-2765(21)00542-6. doi: 10.1016/j.molcel.2021.06.031. Epub ahead of print. PMID: 34352207. View PDF
  • Ahmed KT, Sun J, Chen W, Martinez I, Cheng S, Zhang W, Yong J, Zhang W. In silico model for miRNA-mediated regulatory network in cancer. Brief Bioinform. 2021 Jul 19:bbab264. doi: 10.1093/bib/bbab264. Epub ahead of print. PMID: 34279571. View PDF

2020

  • Moreno C †, Santos RM †, Burns R †, Zhang WC. Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases. Cancers (Basel). 2020 Nov 3;12(11):3237. doi: 10.3390/cancers12113237. PMID: 33153035; PMCID: PMC7693138. († These authors contributed equally to this work. Undergraduate: Moreno C., Santos R.M., and Burns R.) View PDF
  • Nagarajan MB, Tentori AM, Zhang WC, Slack FJ, Doyle PS. Spatially resolved and multiplexed MicroRNA quantification from tissue using nanoliter well arrays. Microsyst Nanoeng. 2020 May 9;6:51. doi: 10.1038/s41378-020-0169-8. PMID: 32419951; PMCID: PMC7211184. View PDF
  • Santos RM †, Moreno C †, Zhang WC. Non-Coding RNAs in Lung Tumor Initiation and Progression. Int J Mol Sci. 2020 Apr 16;21(8):2774. doi: 10.3390/ijms21082774. PMID: 32316322; PMCID: PMC7215285. († These authors contributed equally to this work. Undergraduate: Santos R.M. and Moreno C.) View PDF
  • Rupaimoole R, Yoon B, Zhang WC, Adams BD, Slack FJ. A High-Throughput Small Molecule Screen Identifies Ouabain as Synergistic with miR-34a in Killing Lung Cancer Cells. iScience. 2020 Feb 21;23(2):100878. doi: 10.1016/j.isci.2020.100878. Epub 2020 Feb 1. PMID: 32062455; PMCID: PMC7031322. View PDF

2019

  • Zhang WC. microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance. Int J Mol Sci. 2019 Dec 3;20(23):6094. doi: 10.3390/ijms20236094. PMID: 31816897; PMCID: PMC6928693. View PDF
  • Zhang WC, Wells JM, Chow KH, Huang H, Yuan M, Saxena T, Melnick Mary Ann, Politi K, Asara JM, Costa DB, Bult CJ, Slack FJ. miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma. Nature Metabolism. 2019 Apr;1(4):460-474. doi: 10.1038/s42255-019-0052-9. Epub 2019 Apr 8. PMID: 31535082; PMCID: PMC6750230.

2018

  • Choe J, Lin S, Zhang W, Liu Q, Wang L, Moya JAR, Du P, Kim WT, Tang S, Sliz P, Richards WG, Wong KK, Locker N, Slack F, Gregory RI. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 Sep;561(7724):556-560.
  • Nagarajan MB, Tentori AM, Zhang WC, Slack FJ, Doyle PS. Nonfouling, encoded hydrogel microparticles for multiplex microRNA profiling directly from formalin-fixed, paraffin embedded tissue. Anal Chem. 2018 Sep 4;90(17):10279-85.
  • Tentori AM, Nagarajan MB, Kim JJ, Zhang WC, Slack FJ, Doyle PS. Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays. Lab Chip. 2018 Aug 7;18(16):2410-24.

2017

  • Zhang WC and Slack FJ. MicroRNA-21 mediates resistance to EGFR tyrosine kinase inhibitors in lung cancer. J Thoracic Oncology. 2017; 12 (8), S1536.
  • Adams BD, Parsons C, Walker L, Zhang WC, Slack FJ. Targeting noncoding RNAs in disease. J Clin Invest. 2017 Mar 1;127(3):761-771.

2016

  • Zhang WC, Slack FJ. ADARs edit microRNAs to promote leukemic stem cell activity. Cell Stem Cell. 2016 Aug 4;19(2):141-2. View PDF
  • Zhang WC, Chin TM, Yang H, Nga ME, Lunny DP, Lim EK, Sun LL, Pang YH, Leow YN, Malusay SR, Lim PX, Lee JZ, Tan BJ, Shyh-Chang N, Lim EH, Lim WT, Tan DS, Tan EH, Tai BC, Soo RA, Tam WL, Lim B. Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression. Nat Commun. 2016 Jun 21;7:11702. View PDF
  • Yong KJ, Basseres DS, Welner RS, Zhang WC, Yang H, Yan B, Alberich-Jorda M, Zhang J, de Figueiredo-Pontes LL, Battelli C, Hetherington CJ, Ye M, Zhang H, Maroni G, O’Brien K, Magli MC, Borczuk AC, Varticovski L, Kocher O, Zhang P, Moon YC, Sydorenko N, Cao L, Davis TW, Thakkar BM, Soo RA, Iwama A, Lim B, Halmos B, Neuberg D, Tenen DG, Levantini E. Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression. Sci Transl Med. 2016 Aug 3;8(350):350ra104

2014

  • Go MK, Zhang WC, Lim B, Yew WS. Glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis. Biochemistry. 2014 Feb 11;53(5):947-56.
  • Hoe SL, Tan LP, Jamal J, Peh SC, Ng CC, Zhang WC, Ahmad M, Khoo AS. Evaluation of stem-like side population cells in a recurrent nasopharyngeal carcinoma cell line. Cancer Cell Int. 2014 Oct 9;14(1):101.

2012

  • Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, Soh BS, Sun LL, Tai BC, Nga ME, Bhakoo KK, Jayapal SR, Nichane M, Yu Q, Ahmed DA, Tan C, Sing WP, Tam J, Thirugananam A, Noghabi MS, Pang YH, Ang HS, Mitchell W, Robson P, Kaldis P, Soo RA, Swarup S, Lim EH, Lim B. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell. 2012 Jan 20;148(1-2):259-72. View PDF
  • Soh BS, Zheng D, Li Yeo JS, Yang HH, Ng SY, Wong LH, Zhang W, Li P, Nichane M, Asmat A, Wong PS, Wong PC, Su LL, Mantalaris SA, Lu J, Xian W, McKeon F, Chen J, Lim EH, Lim B. CD166(pos) subpopulation from differentiated human ES and iPS cells support repair of acute lung injury. Mol Ther. 2012;20(12):2335-46.

A full list of publications can be found on PubMed and GoogleScholar