Selected peer-reviewed articles
Shiquan Cui, Tingting Zhang, Xinrui Xiong, Jihe Zhao, Qilin Cao, Hongxia Zhou, Xu-Gang Xia. Detergent-Insoluble PFN1 Inoculation Expedites Disease Onset and Progression in PFN1 Transgenic Rats. Frontiers in Neurosciences. 2023.1279259. FULL TEXT
Shurui Cai, Na Li, Xuetao Bai, Lu Liu, Ananya Banerjee, Kousalya Lavudi, Xiaoli Zhang, Jihe Zhao, Monica Venere, Wenrui Duan, Junran Zhang, Meng X. Welliver, Kai He, Qi-En Wang. ERK inactivation enhances stemness of NSCLC cells via promoting Slug-mediated epithelial-to-mesenchymal transition. Theranostics 2022, Vol. 12, Issue 16. 7051-7066. FULL TEXT
Debarati Mukherjee, Jie Hao, Satadru K. Lahiri, Heng Lu, Lin Yu, and Jihe Zhao. KLF8 Promotes Invasive Outgrowth of Breast Cancer by Inducing Filopodium-like Protrusions via CXCR4. Am J Transl Res. 2022 Feb 15; 14(2):1220-1233. FULL TEXT
Hao J, Yu L, Lu H, Sakthivel TS, Seal S, Liu B, Zhao J. Sensitization of breast cancer to Herceptin by redox active nanoparticles. Am J Cancer Res. 2021 Oct 15;11(10):4884-4899. FULL TEXT
Hao J, Lu H, Mukherjee D, Yu L, Zhao J. Role of krüppel-like factor 8 for therapeutic drug-resistant multi-organ metastasis of breast cancer. Am J Cancer Res. 2021 May 15;11(5):2188-2201. FULL TEXT
Yuan G, Cui S, Chen X, Song H, Huang C, Tong J, Yuan Z, Yu L, Xiong X, Zhao J, Huang B, Wu Q, Zhou Y, Chen G, Zhou H, and Xia X-G. Detergent-insoluble inclusion constitutes the first pathology in PFN1 transgenic rats. J Neurochem. 2021 May;157(4):1244-1252. FULL TEXT
Sun A, Hao J, Yu L, Lahiri SK, Yang W, Lin Q, Zhao J. Regulation of Krüppel-like factor 8 by the NEDD4 E3 ubiquitin ligase. Am J Transl Res. 2019 Mar 15;11(3):1521-1530. FULL TEXT
Wason MS, Lu H, Yu L, Lahiri SK, Mukherjee D, Shen C, Das S, Seal S, J Zhao. Cerium Oxide Nanoparticles Sensitize Pancreatic Cancer to Radiation Therapy through Oxidative Activation of the JNK Apoptotic Pathway. Cancers. 2018 Sep 1;10(9). pii: E303. FULL TEXT
Satadru K. Lahiri, Heng Lu, Debarati Mukherjee, Lin Yu and Jihe Zhao. ERK2 Phosphorylates Krüppel-like Factor 8 Protein at Serine 48 to Maintain Its Stability. American Journal of Cancer Research. 2016;6(5):910-923. FULL TEXT
Debarati Mukherjee, Heng Lu, Lin Yu, Chunjiang He, Satadru K. Lahiri, Tianshu Li, and Jihe Zhao. Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis. Oncotarget. 2016;26;7(17):23552-68. Full Text
Tianshu Li, Heng Lu, Debarati Mukherjee, Satadru K. Lahiri, Chao Shen, Lin Yu and Jihe Zhao. Identification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancer. Oncotarget. 2015 Aug 28;6(25):21428-42. Full Text
Xuan Xiang, Xiang Zhao, Hongxia Qu, Dan Li, Dehua Yang, Jiarui Pu, Hong Mei, Jihe Zhao, Kai Huang, Liduan Zheng, and Qiangsong Tong. Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14. Cancer Letters 359 (2015) 187–197. Full Text
Xuan Xiang, Hong Mei, Xiang Zhao, Jiarui Pu, Dan Li, Dehua Yang, Hongxia Qu, Jihe Zhao, Kai Huang, Liduan Zheng and Qiangsong Tong. Promoter-targeting miRNA-337-3p exerts tumor suppressive functions in neuroblastoma by epigenetic repression of matrix metalloproteinase 14. Oncotarget. 2015. Sep 8;6(26):22452-66. Full Text
Prosdocimo DA1, Anand P, Liao X, Zhu H, Shelkay S, Artero-Calderon P, Zhang L, Kirsh J, Moore D, Rosca MG, Vazquez E, Kerner J, Akat KM, Williams Z, Zhao J, Fujioka H, Tuschl T, Bai X, Schulze PC, Hoppel CL, Jain MK, Haldar SM. Kruppel-like Factor 15 Is a Critical Regulator of Cardiac Lipid Metabolism. J Biol Chem. 2014 Feb 28;289(9):5914-24. Full Text
Lu H, Hu L, Yu L, Wang X, Urvalek AM, Li T, Shen C, Mukherjee D, Lahiri SK, Wason MS, Zhao J. KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. Oncogene. 2014 May 29;33(22):2909-17. Full Text PMC
Lu H, Wang X, Urvalek AM, Li T, Xie H, Yu L, Zhao J. Transformation of human ovarian surface epithelial cells by Krüppel-like factor 8. Oncogene. 2014 Jan 2;33(1):10-8. Full Text PMC
Li T, Lu H, Shen C, Lahiri SK, Wason MS, Mukherjee D, Yu L, Zhao J. Identification of epithelial stromal interaction 1 as a novel effector downstream of Krüppel-like factor 8 in breast cancer invasion and metastasis. Oncogene. 2014 Sep 25;33(39):4746-55. Full Text PMC
Wang X, Lu H, Li T, Yu L, Liu G, Peng X, Zhao J. Krüppel-like factor 8 promotes tumorigenic mammary stem cell induction by targeting miR-146a. Am J Cancer Res. 2013 Aug 14;3(4):356-73. Full Text
Heng Lu, Qishan Lin and Jihe Zhao. Identification of Signaling Protein Complexes by Parallel Affinity Precipitation Coupled with Mass Spectrometry. Cell Communication Insights 2013:5 1–7. Full Text
Lu H, Hu L, Li T, Lahiri S, Shen C, Wason MS, Mukherjee D, Xie H, Yu L, Zhao J. A novel role of Kruppel-like factor 8 in DNA repair in breast cancer cells. J Biol Chem. 2012 Dec 1;287(52):43720-9. Full Text
Wason MS, Colon J, Das S, Seal S, Turkson J, Zhao J, Baker CH. Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production. Nanomedicine: Nanotech Biol Med 2013 May;9(4):558-69. Full Text PMC
Zhang X, Yue P, Page BD, Li T, Zhao W, Namanja AT, Paladino D, Zhao J, Chen Y, Gunning PT, Turkson J. Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9623-8. Full Text
Lu H, Wang X, Li T, Urvalek AM, Yu L, Li J, Zhu J, Lin Q, Peng X, Zhao J. 2011. Identification of PARP-1 as a novel Kruppel-like factor 8 interacting and regulating protein. J Biol Chem. 2011 Jun 10;286(23):20335-44. Full Text
Urvalek AM, Lu H, Wang X, Li T, Yu L, Zhu J, Lin Q, Zhao J. 2011. Regulation of the oncoprotein KLF8 by a switch between acetylation and sumoylation. Am J Transl Res. 2011 Feb;3(2):121-32. Full Text
Wang X, Lu H, Urvalek AM, Li T, Yu L, Lamar J, Dipersio CM, Feustel PJ, Zhao J. 2011. KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9. Oncogene. 2011 Apr 21;30(16):1901-11. Full Text PMC
Kara Mitchell, Kimberly B. Svenson, Whitney M. Longmate, Katerina Gkirtzimanaki, Rafal Sadej, Xianhui Wang, Jihe Zhao, Aristides G. Eliopoulos, Fedor Berditchevski, and C. Michael DiPersio. 2010. Suppression of integrin α3β1 in breast cancer cells reduces COX-2 gene expression and inhibits tumorigenesis, invasion, and crosstalk to endothelial cells. Cancer Res. 2010 Aug 1;70(15):6359-67. Full Text
Urvalek, A.M., Wang, X., Lu, H., and J. Zhao, J. (2009). KLF8 recruits the p300 and PCAF co-activators to its amino terminal activation domain to activate transcription. Cell Cycle. 9(3): 601-611. Commented in: Evans, P.M. and Liu, C. (2010). New insights into KLF8-mediated transactivation. Cell Cycle. 9(4):649-650; Lloyd, J.A. (2010). KLF8 sets the pace for the cell cycle through interactions with p300 and PCAF. Cell Cycle. 9(4):650-651. Full Text
Tina S. Mehta, Heng Lu, Xianhui Wang, Kim-Hang H. Nguyen, Alison M. Urvalek, Farah Monzur, Joho D. Hammond, Jameson Q. Ma and Jihe Zhao. 2009. A unique sequence in the N-terminal regulatory region controls the nuclear localization of Kruppel-like factor 8 by cooperating with the C-terminal zinc-fingers. Cell Research. 2009 Sep;19(9):1098-109. Commented in: Cell Research. 2009 Sep;19(9):1041-3. Full Text
Xianhui Wang, Alison M. Urvalek, Jinsong Liu and Jihe Zhao. 2008. Activation of KLF8 transcription by FAK in human ovarian epithelial and cancer cells. J Biol Chem. 2008 May 16;283(20):13934-42. Full Text
Wang, X., M Zheng, G Liu, C. W Xia, P McKeown-Longo, M-C Hung, and Jihe Zhao. 2007. Kruppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Cancer Res. 67(15): 7184-7193. Full Text
Wang, X., and Zhao, J. 2007. Kruppel-like factor 8 participates in oncogenic transformation. Oncogene 26:456-61. Full Text
Wei, H., Wang, X., Gan, B., Urvalek, A.M., Melkoumian, Z.K., Guan, J-L., and Zhao, J. 2006. SUMO modification of KLF8 and its role in the regulation of KLF8 transcriptional activity. J Biol Chem 281:16664-71. Full Text
Zhao, J., Bian, Z.C., Yee, K., Chen, B.P.C., Chien, S., Guan, J-L. 2003. Identification of the transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Molecular Cell 11:1503-15. Full Text
Abbi, S., H. Ueda, C. Zheng, L. A. Cooper, J. Zhao, R. Christopher, and J. L. Guan. 2002. Regulation of focal adhesion kinase by a novel protein inhibitor FIP200. Mol Biol Cell 13:3178-91. Full Text
Xie, B., J. Zhao, M. Kitagawa, J. Durbin, J. A. Madri, J. L. Guan, and X. Y. Fu. 2001. Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion. J Biol Chem 276:19512-23. Full Text
Yang, W., Q. Lin, J. Zhao, J. L. Guan, and R. A. Cerione. 2001. The nonreceptor tyrosine kinase ACK2, a specific target for Cdc42 and a negative regulator of cell growth and focal adhesion complexes. J Biol Chem 276:43987-93. Full Text
Zhao, J., R. Pestell, and J. L. Guan. 2001. Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression. Mol Biol Cell 12:4066-77. Full Text
Zhao, J., C. Zheng, and J. Guan. 2000. Pyk2 and FAK differentially regulate progression of the cell cycle. J Cell Sci 113 (Pt 17):3063-72. Full Text
Reiske, H. R., J. Zhao, D. C. Han, L. A. Cooper, and J. L. Guan. 2000. Analysis of FAK-associated signaling pathways in the regulation of cell cycle progression. FEBS Lett 486:275-80. Full Text
Zhao, J. H., H. Reiske, and J. L. Guan. 1998. Regulation of the cell cycle by focal adhesion kinase. J Cell Biol 143:1997-2008. Full Text
Zhao, J. H., T. Inoue, W. Shoji, Y. Nemoto, and M. Obinata. 1998. Direct association of YY-1 with c-Myc and the E-box binding protein in regulation of glycophorin gene expression. Oncogene 17:1009-17. Full Text
Yajima, H., M. Takao, S. Yasuhira, J. H. Zhao, C. Ishii, H. Inoue, and A. Yasui. 1995. A eukaryotic gene encoding an endonuclease that specifically repairs DNA damaged by ultraviolet light. EMBO J 14:2393-9. Full Text
Zhao, J. H., H. Tohda and A. Oikawa. 1992. Camptothecin-induced sister-chromatid exchange dependent on the presence of bromodeoxyuridine and the phase of the cell cycle. Mutat Res 282:49-54. Full Text
Tohda, H., J. H. Zhao and A. Oikawa. 1992. A possible involvement of DNA topoisomerase I in “caffeine effect” after ultraviolet irradiation. Tohoku J Exp Med 168:129-32. Full Text
Chapters/Reviews
Jihe Zhao. Cancer Stem Cells and Chemoresistance: The Smartest Survives the Raid. Pharmacology and therapeutics. 2016 Apr;160:145-58. Full Text
Justin Gray and Jihe Zhao. The implications of Epithelial Stromal Interaction 1 in Diseases Associated with Inflammatory Signaling. Cell Communication Insights. 2016; 8: 1-6. Full Text
Jihe Zhao. KLF8: so different in ovarian and breast cancer. Oncoscience. 2014. 1:248-9. Full Text
Melissa S Wason, Jihe Zhao. Cerium oxide nanoparticles: potential applications for cancer and other diseases. Am J Transl Res 2013;5(2):126-131. Full Text
Mukherjee D., and Zhao, J. The Role of chemokine receptor CXCR4 in breast cancer metastasis. Am J Cancer Res. 2013;3(1):46-57. Full Text
Lahiri SK, Zhao J. Krüppel-like factor 8 emerges as an important regulator of cancer. Am J Transl Res. 2012;4(3):357-63. Full Text
Mehta TS, Monzur F, Zhao J. 2010. Determination of nuclear localization signal sequences for Krüppel-like factor 8. Transcription Factors, Methods Mol Biol. 2010;647:171-86. Full Text PMC
Zhao, J. 2008. Signal transduction Based Drug Discovery – from Benchtop to Bedside. Fundamental Medical Pharmacoloy. Jilin Science Technology Publishing House. Chapter 9, p67-75.
J. Zhao and J-L. Guan. 2009. Signal Transduction by Focal Adhesion Kinase in Cancer. Cytoskeleton Signaling in Cancer, Chapter 4. Cancer and Metastasis 2009, Vol28, p35-49. Full Text
Zhao, J. 2007. Sumoylation regulates diverse biological processes. Cell Mol Life Sci. 2007 Dec;64(23):3017-33. Full Text
Zhao, J., Guan, JL. 2000. Role of focal adhesion kinase in signaling by the extracellular matrix. Prog Mol and Subcell Biol, vol. 25. p. 37-55.