Publications

Research articles:

  1. Amagai M, Matsuyoshi N, Wang ZH, Andl C, Stanley JR. Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. Nature Medicine 2000 Nov;6(11):1275-7.
  2. Andl CD, Stanley JR. Central role of the plakoglobin-binding domain for desmoglein 3 incorporation into desmosomes. J Invest Dermatol. 2001 Nov;117(5):1068-74.
  3. Andl CD, Mizushima T, Nakagawa H, Oyama K, Harada H, Chruma K, Herlyn M, Rustgi AK. Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo. J Biol Chem. 2003 Jan 17;278(3):1824-30. Epub 2002 Nov 14.
  4. Harada H, Nakagawa H, Oyama K, Takaoka M, Andl CD, Jacobmeier B, von Werder A, Enders GH, Opitz OG, Rustgi AK. Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation. Mol Cancer Res. 2003 Aug;1(10):729-38.
  5. Takaoka M, Harada H, Deramaudt TB, Oyama K, Andl CD, Johnstone CN, Rhoades B, Enders GH, Opitz OG, Nakagawa H. Ha-Ras(G12V) induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction. Oncogene. 2004 Sep 2;23(40):6760-8.
  6. Andl CD, Mizushima T, Oyama K, Bowser M, Nakagawa H, Rustgi AK. EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes. Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287(6):G1227-37.
  7. Takaoka M, Harada H, Andl CD, Oyama K, Naomoto Y, Dempsey KL, Klein-Szanto AJ, El-Deiry WS, Grimberg A, Nakagawa H. Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3. Cancer Res. 2004 Nov 1;64(21):7711-23
  8. Bosch FX, Andl C, Abel U, Kartenbeck J. E-cadherin is a selective and strongly dominant prognostic factor in squamous cell carcinoma: a comparison of E-cadherin with desmosomal components. Int J Cancer. 2005 May 1;114(5):779-90
  9. Takaoka M, Smith CE, Mashiba MK, Okawa T, Andl CD, El-Deiry WS, and Nakagawa H: EGF-mediated regulation of insulin-like growth factor binding protein (IGFBP)-3 determines esophageal epithelial cellular response to IGF-I. Journal of Physiology-Gastrointestinal and Liver Physiology. 2006; 290:G404-16.
  10. Andl CD, Fargnoli BB, Okawa T, Bowser M, Takaoka M, Nakagawa H, Klein-Szanto A, Hua X, Herlyn M and Rustgi AK: Coordinated functions of E-cadherin and TGFb receptor II in vitro and in vivo. Cancer Research. 2006; 66: 9878-9885
  11. Andl T, Murchinson EP, Fei L, Zhang Y, Yunta-Gonzales M, Tobias JW, Andl CD, Seykora JT, Hannon GJ & Millar SE. The miRNA-processing enzyme Dicer is essential for the morphogenesis and maintenance of hair follicles. Current Biology. 2006 May 23: 16:1-9.
  12. Lioni M, Brafford P, Andl C, Rustgi A, El-Deiry W, Herlyn M and Smalley Loss of Claudin-7 regulates E-cadherin expression and increases invasion in Esophageal Squamous Cell Carcinoma. Am J Pathol. 2007, 170 (2): 709-721.
  13. Oyama K, Okawa T, Nakagawa H, Takaoka M, Andl, CD, Kim SH, Klein-Szanto A, Herlyn M, El-Deiry W and Rustgi AK: AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture. Oncogene, 2007, 26(16):2353-64
  14. Takaoka M, Kim SH, Okawa T, Michaylira CZ, Stairs DB, Johnstone CN, Andl CD, Rhoades B, Lee JJ, Klein-Szanto AJ, El-Deiry WS, Nakagawa H. IGFBP-3 Regulates Esophageal Tumor Growth Through IGF-Dependent and Independent Mechanisms. Cancer Biol Ther. 2007;6(4)
  15. Okawa T, Michaylira CZ, Kalabis J, Stairs DB, Nakagawa H, Andl C, Johnstone CN, Klein-Szanto AJ, El-Deiry WS, Cukierman E, Herlyn M and Rustgi AK. The functional interplay between EGFR overexpression, hTERT activation and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induce tumor development, invasion and differentiation. Genes Dev. 2007; 21(21):2788-803.
  16. Andl CD*, McCowan K, Allison, GL and Rustgi, AK. Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner. Neoplasia. 2010; 12(6):485-98.*corresponding author
  17. Zaika E, Wei J, Yin D, Andl C, Moll U, El-Rifai W, Zaika A. p73 protein regulates DNA damage repair. FASEB J 2011; 25(12):4406-14.
  18. Le Bras GF, Richards N, Allison G, McCowan KM, Andl CD. CD44 upregulation in E-cadherin negative esophageal cancer results in cell invasion. PLoS ONE 2011; 6(11): e27063. 5
  19. Kadaba R, Birke H, Wang J, Hooper S, Andl CD, DiMaggio F, Soylu E, Ghallab M, Bor D, Froeling FEM, Bhattacvharya S, Rustgi AK, Sahai E, Chelala C, Sasieni P, Kocher HM. Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes. J. Pathol. 2013; 230(1):107-17.
  20. Le Bras GF, Loomans HA, Taylor CJ, Revetta FL, Andl CD. Activin A balance regulates epithelial invasiveness and tumorigenesis. Lab Invest. 2014; 94(10):1134-46.
  21. Andl T, Le Bras GF, Richards NF, Allison GL, Washington MK, Lee RK, Loomans HA, Taylor C, Moses HL, Andl CD. Concerted loss of TGFb-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma. Carcinogenesis. 2014; Nov;35(11):2602-10.
  22. Le Bras GF, Taylor C, Koumangoye RB, Revetta F, Loomans HA, Andl CD. TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion. Exp Cell Res. 2015, 330(1):29-42.
  23. Bhardwaj V, Noto JM, Wei J, Andl C, El-Rifai W, Peek RM, Zaika A. Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway. Oncotarget. 2015, 6(3):1531-43.
  24. Koumangoye RB, Andl T, Taubenslag, KJ, Zilberman ST, Taylor CJ, Loomans, HA, Andl CD. SOX4 directly bind to EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells. Molecular Cancer. 2015, 14(1):24-.
  25. Taylor C, Le Bras GF, Loomans HA, Koumangoye RB, Andl CD. Activin A signaling induces cell invasion and regulates EMT marker expression in esophageal adenocarcinoma. Oncotarget. 2015, 6(33):34228-44.
  26. Arnold SA, Loomans HA, Matusik RJ, Ketova T, Clark PE, Andl CD, Zijlstra A. Urinary oncofetal ED-A fibronectin confers poor prognosis in patients with bladder cancer. Clin.Exp. Metastasis.  2015, Oct 11.
  27. Andl CD, Le Bras GF, Loomans HA, Kim A, Zhou LL, Zhang Y, Andl T. Association of TGFβ signaling with the maintenance of a quiescent stem cell niche in human oral mucosa. Histochem Cell Biol.2016. 146(5):539-555. PMID:27480259.
  28. Simonik EA, Cai Y, Kimmelshue KN, Brantley-Sieders DM, Loomans HA, Andl CD, Westlake GM, Youngblood VM, Chen J, Yarbrough WG, Brown BT, Nagarajan L, Brandt SJ. LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer). PLoS One. 2016, Oct 25;11(10):e0164804
  29. Loomans HA, Arnold SA, Quast LL, Andl CD. Esophageal squamous cell carcinoma is inhibited by Activin A in ACVRIB-positive cells.BMC Cancer.2016 Nov 9;16(1):873.PMID: 27829391,PMCID: PMC5101642.
  30. Loomans HA, Arnold SA, Hebron K, Taylor CJ, Zijlstra A, Andl CD. Loss of ACVRIB leads to increased squamous cell carcinoma aggressiveness through alterations in cell-cell and cell-matrix adhesion proteins.  Am J Cancer Res. 2017 Dec 1;7(12):2422-2437. PMID:29312797, PMCID:PMC5752694
  31. Roudebush C, Catala-Valentin A, Andl T, Le Bras G, Andl C. Activin A-mediated epithelial de-differentiation contributes to injury repair in an in vitro gastrointestinal reflux model. Cytokine. 2019 Nov;123:154782. doi: 10.1016/j.cyto.2019.154782. PMID:31369967
  32. Farmer S, Andl CD. Computational modeling of Activin A regulation and formation of receptor-promiscuous signaling complexes through a transforming growth factor β-like binding.  J Biomol Struct Dyn. 2020 Jun 27:1-16. doi: 10.1080/07391102.2020.1785330. PMID: 32597324

Review articles (peer reviewed):

  1. Andl CD, Rustgi AK. No one-way street: cross-talk between E-cadherin and receptor tyrosine kinase (RTK) signaling: a mechanism to regulate RTK activity. Cancer Biol Ther. 2005 Jan;4(1):28-31
  2. Andl CD. The Misregulation of Cell Adhesion Components during Tumorigenesis: Overview and Commentary. J Oncol. 2010, 2010. PMID: 20953359,PMCID: PMC2952821
  3. Le Bras GF, Taubenslag KJ, Andl CD. The regulation of cell-cell adhesion during epithelial-mesenchymal-transition, motility and tumor progression. Cell Adh Migr. 2012; 6(4). PMID: 22796940; PMCID: PMC3478259
  4. Loomans HA, Andl CD. Intertwining of Activin A and TGFβ signaling: dual roles in cancer progression and cancer cell invasion. Special Issue on Cancer Cell Cancers 2015, 7(1), 70-91; doi:10.3390/cancers7010070
  5. Le Bras GF, Farooq MH, Falk GW, Andl CD.Esophageal cancer: The latest on chemoprevention and state of the art therapies.Pharmacol Res. 2016 Aug 24;113(Pt A):236-244. doi: 10.1016/j.phrs.2016.08.021., PMID: 27565381
  6. Loomans HA, Andl CD. Activin receptor-like kinases: a diverse family playing an important role in cancer. American J Cancer Res. 2016. 2016 Nov 1;6(11):2431-2447. eCollection 2016. Review.

Textbooks, by invitation:

Andl CD. E-cadherin and its interaction with cell signaling receptors, Molecular and Functional Diversities of Cadherin and Protocadherin (ISBN 978-81-308-0427-9), 201