About Terri Finkel, M.D., Ph.D.

 

Terri H. Finkel, M.D., Ph.D., is a pediatric rheumatologist and immunologist. She serves as the Chair of Pediatrics and Chief Scientific Officer at Nemours Children’s Hospital in Lake Nona Medical City, Orlando, Florida and Professor of Pediatrics and Biomedical Sciences at the University of Central Florida College of Medicine. Dr. Finkel received her medical degree in 1982 and PhD in biochemistry/biophysics in 1984 from Stanford University.

Dr. Finkel has been an NIH-funded investigator since 1990, studying the mechanisms of immune dysfunction in autoimmune and infectious disease. Her work has been recognized by more than 100 publications, 9 issued patents or patents pending, and research grants totaling more than $12 million. Among her awards and honors are those from the American College of Rheumatology, American Foundation for AIDS Research, Arthritis Foundation, Colorado Women’s Hall of Fame, Henry Kunkel Society, Lupus Foundation, and the Pediatric AIDS Foundation.

In 1999, Dr. Finkel was recruited to lead the Division of Rheumatology at The Children’s Hospital of Philadelphia, as the Joseph Lee Hollander Chair of Pediatric Rheumatology and Professor of Pediatrics at the University of Pennsylvania School of Medicine. She was recruited to Nemours in 2012 to build a Department of Pediatrics and Research Institute at the first free-standing children’s hospital to be built in America in three decades. Nemours Children’s Hospital has cared for more than 80,000 children and families since opening in October 2012, and has established strategic partnerships with area hospitals, physician practices, and academic institutions, and a successful research enterprise, with more than 60 clinical research studies in progress and external research funding of over $6 million. In 2014, Dr. Finkel’s biography was read in the U.S. House of Representatives and officially entered in the Congressional Record, in honor of her leadership and contributions to healthcare.

Recent Publications

Zhang, M., Ma, Z., Selliah, N., Weiss, G., Genin, A., Finkel, T.H., Cron, R.Q. The impact of Nucleofection on the activation state of primary human CD4 T cells. Journal of Immunological Methods 408:123-131, 2014.

Ma, Z., LeBard, D.N., Loverde S.M., Sharp, K.A., Klein, M.L., Discher, D.E., Finkel, T.H.: TCR triggering by pMHC ligands tethered on surfaces via poly (ethylene glycol) depends on polymer length. PLoS ONE 2014 Nov 10;9(11):e112292. doi: 10.1371/journal.pone.0112292. eCollection 2014.

Yan, J., Tingey C., Lyde, R., Gorham, T.C., Choo, D.K., Muthumani, A., Myles, D., Weiner, L.P., Kraynyak, K.A., Reuschel, E.L., Finkel, T.H., Kim, J.J., Sardesai, N.Y., Ugen, K.E., Muthumani, K., Weiner, D.B.: Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model. Cancer Gene Therapy 2014 Dec;21(12):507-17. doi: 10.1038/cgt.2014.56. Epub 2014 Nov 14.

Ellis, J.A., Scurrah, K.J., Li, Y.R., Ponsonby, A.L., Chavez, R.A., Pezic, A., Dwyer, T., Akikusa, J.D., Allen, R.C., Becker, M.L., Thompson, S.D., Lie, B.A., Flatø, B., Førre, O., Punaro, M., Wise, C., Finkel, T.H., Hakonarson, H., Munro, J.E.: Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis. Journal of Steroid and Biochemical Molecular Biology. 2015 Jan;145:113-20. doi: 10.1016/j.jsbmb.2014.10.012. Epub 2014 Oct 18.

Ellis, J.A Chiaroni-Clarke, R.C., Li, Y.R., Munro, J.E., Chavez, R.A., Scurrah, K.J., Pezic, A., Akikusa, J.D., Allen, R.C., Piper, S.E., Becker, M.L., Thompson, S.D., Lie, B.A., Flato, B., Forre, O., Punaro, M., Wise, C., Saffery, R., Finkel, T.H., Hakonarson, H., Ponsonby, A.L.: The association of PTPN22 rs2476601 with Juvenile Idiopathic Arthritis is specific to females. Genes & Immunity, 2015 Aug 20. doi: 10.1038/gene.2015.32. [Epub ahead of print]

Li, Y.R., Li, J., Zhao, S.D., Bradfield, J., Mentch, F., Maggadottir, SM., Hou, C., Abrams, D., Chang, D., Gao, F., Guo, Y., Wei, Z., Connoly, J., Cardinale, C., Bakay, M., Glessner, J., Kao, C., Thomas, K.A., Qui, H., Chiavacci, R., Kim, C., Wang, F., Snyder, J., Richie, M.D., Flatø, B., Førre, O. Denson L., Thompson, S.D., Becker, M.L., Guthery, S.L., Latiano, A., Perez, E., Resnick, E., Russell, R.K., Wilson, D.C., Silverberg, M.S., Annese, V., Lie, B.A., Punaro, M., Dubinsky, M., Monos, D., Strisciuglio, C., Staiano, A., Miele, E., Kugathasan, S., Ellis, J.A., Munro, J.E., Sullivan. K., Wise, C., Chapel, H., Cunningham-Rundles, C., Grant, S.F.A., Orange, J.S., Sleiman, P.S., Behrens, E.M., Griffiths, A., Satsangi, J., Finkel, T.H., Keinan, A., Luning Prak, E.T., Polychronakos, C., Baldassano, R.H., Li, H., Keating, B., Hakonarson, H.: Meta analysis of shared genetic architecture in pediatric autoimmune diseases. Nature Medicine, 2015 Sep;21(9):1018-27. doi: 10.1038/nm.3933. Epub 2015 Aug 24.

Li, Y.R., Zhao, S.D., Li, J., Bradfield, J., Mohebnasab, M.,, Steel, L.,, Kobie, J., Abrams, D., Mentch, F., Glessner, J., Guo, Y., Wei, Z., Connolly, J., Cardinale, C., Bakay, Li, D., Maggadottir, S.M., Thomas, K.A., Qui, H., Chiavacci, R., Kim, C., Wang, F., Snyder, J., Flatø, B., Førre, O., Denson L., Thompson, S.D., Becker, M.L., Guthery, S.L., Latiano, A., Perez, E., Resnick, E., Strisciuglio, C., Staiano, A., Miele, E., Silverberg, M.S., Lie, B.A., Punaro, M., Russell, R.K., Wilson, D.C., Dubinsky, M., Monos, D., Annese, V., Munro, J.E., Wise, C., Chapel, H., Cunningham-Rundles, C., Orange, J.S., Behrens, E.M., Sullivan, K., Kugathasan, S., Griffiths, A., Satsangi, J., Grant, S.F.A., Sleiman, P.S., Finkel, T.H., Polychronakos, C., Baldassano, R.H., Luning Prak, E.T., Ellis, J.A., Li, H., Keating, B., Hakonarson, H.: Genetic sharing and heritability of pediatric age of onset autoimmune diseases. Nature Communications, 2015 Oct 9;6:8442. doi: 10.1038/ncomms9442.

Reuschel, E.L., Wang, J.F., Shivers, D.K., Muthumani, K., Weiner, D.B., Zhengyu, M., Finkel, T.H.: REDD1 is essential for optimal T cell proliferation and survival. PLoS ONE, 2015 Aug 24; 10(8):e0136323. doi: 10.1371/journal.pone.0136323. eCollection 2015.