About Otto Phanstiel IV, Ph.D.

Dr. Otto Phanstiel is an active educator at the College of Medicine. He teaches primarily in the core course of the Biomedical Sciences PhD program and as a small-group discussion leader in Human Body 1 module in the medical school.

In addition to his teaching responsibilities at the College of Medicine, Dr. Phanstiel conducts funded research in medicinal chemistry. His research lab develops new therapies to fight cancer and infectious diseases.

The cancer projects focus on the development of new drugs which target cells through their polyamine transporter activity and block the spread of metastatic cancers to other tissues. The development of novel polyamine transport inhibitors provides a method to starve cancers of key polyamine metabolites which limits their growth and the team has shown significant efficacy in several cancer models in vivo.

New research students will learn how to conduct multistep organic syntheses of novel drug candidates and will assist in the biological evaluation of their own compounds.

Publications and Awards

  • 2015 Polyamines Gordon Research Conference, co-chair
  • 2011 Scholarship of Teaching and Learning Award
  • 2006 UCF Excellence in Undergraduate Teaching Award
  • 2004 Teaching Incentive Program (TIP) Award presented by UCF
  • 2002 Research Incentive Award (RIA) presented by UCF
  • 2002 UCF Excellence in Graduate Teaching Award
  • 2002 UCF Excellence in Undergraduate Teaching Award
  • 2000 Teacher of the Year Award awarded by the UCF ACS student chapter
  • 1999 and 2000 1 of 2 nominated by UCF for the U.S. Professor of the Year Award (e.g., directed by the Council for Advancement and Support of Education). This CASE Award is presented by the Carnegie Foundation for the Advancement of Teaching.
  • 1999 College Excellence in Undergraduate Teaching Award presented by UCF
  • 1999 Teaching Incentive Program (TIP) Award presented by UCF
  • 1999 Distinguished Service Award presented by Lake Highland Preparatory School
  • 1998 Outstanding Teacher of the Year at a Four-Year College Award presented by the Orlando Section of the American Chemical Society
  • 1996 Certificate of Appreciation from the Student Academic Advisory Committee
  • 1995 Cottrell-College Science Award from Research Corporation
  • ATP13A3 and Caveolin-1 as Potential Biomarkers for Difluoromethylornithine-based therapies in Pancreatic Cancers. Meenu Madan, Arjun Patel, Kristen Skruber, Dirk Geerts, Deborah A. Altomare, and Otto Phanstiel IV.  Am. J. Cancer Res., 2016, 6, 1231-1252.
  • Inhibition of Polyamine Uptake Potentiates the Anti-Proliferative Effect of Polyamine Synthesis Inhibition and Preserves the Contractile Phenotype of Vascular Smooth Muscle Cells Grossi, M.; Phanstiel, O.; Rippe, K.; Sward, K.; Alajbegovic, A.; Albinsson, S.; Forte, A.; Persson, L.; Hellstrand, P.; Nilsson, B-O. J. Cell. Physiol. 2015, 9999, 1–9.
  • Synthesis and Biological Evaluation of Anti-metastatic Agents Predicated upon Dihydromotuporamine C and its Carbocyclic Derivatives. Aaron Muth, Veethika Pandey, Navneet Kaur, Melissa Wason, Cheryl Baker, Xianlin Han, Teresa R. Johnson, Deborah A. Altomare, and Otto Phanstiel IV. J. Med. Chem. 2014, 57, 4023-4034.
  • Polyamine transport inhibitors: Design, Synthesis and Combination therapies with Difluoromethylornithine. Aaron Muth, Jennifer Archer, Nicolette Ocampo, Meenu Madan, Luis Rodriguez, and Otto Phanstiel IV. J. Med. Chem. 2014, 57, 348-363.
  • Development of Polyamine Transport Ligands with Improved Metabolic Stability and Selectivity against Specific Human Cancers. Aaron Muth, Joseph Kamel, Navneet Kaur, Allyson C. Shicora, Iraimoudi S. Ayene, Susan K. Gilmour, and Otto Phanstiel IV J. Med. Chem. 2013, 56, 5819-5828.
  • Development of Flavonoid-based Inverse Agonists of the Key signaling receptor US28 of Human Cytomegalovirus. Ana Kralj, Mai-Thao Nguyen, Nuska Tschammer, Nicolette Ocampo, Quinto Gesiotto, Markus R. Heinrich, and Otto Phanstiel, IV. J. Med. Chem. 2013, 56, 5019-5032.
  • Putrescine importer PlaP contributes to swarming motility and urolithelial cell invasion in Proteus mirabilis. Kurihara, S.; Sakai, Y.; Suzuki, H.; Muth, A.; Phanstiel, O.; Rather, P.N. J. Biol. Chem. 2013, 288, 15668-15676.
  • Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites. Niemand, J.; Burger, P.; Verlinden, B.; Reader, J.; Joubert, A.; Kaiser, A.; Louw, A.I.; Kirk, K.; Phanstiel IV, O.; Birkholtz, L-M. Antimicrobial Agents and Chemotherapy. 2013, 57, 2874-2877.
  • Ant 4,4, a polyamine-anthracene conjugate, induces cell death and recovery in human promyelogenous leukemia cells (HL-60). Traquete, R.; Ghani, R.A.; Phanstiel, O.; Wallace, H.M. Amino Acids 2013, 44, 1193-1203.
  • Utilization of Fe3+ -Acinetoferrin Analogues as an iron source by Mycobacterium tuberculosis. Rodriguez, G. M.; Gardner, R. A.; Kaur, N.; Phanstiel IV, O. Biometals 2008, 21, 93-103.
  • A Drosophila model to identify polyamine-drug conjugates that target the polyamine transporter in an intact epithelium. Tsen, C.; Iltis, M.; Kaur, N.; Bayer, C.; Delcros, J-G.; von Kalm, L.; Phanstiel IV, O. J. Med Chem. 2008, 51, 324-330.
  • A Comparison of Chloroambucil- and Xylene-containing polyamines leads to improved ligands for accessing the polyamine transporter. Kaur, N.; Delcros, J-G.; Phanstiel IV, O. J. Med. Chem. 2008, 51, 1393-1401.
  • A Delineation of Diketopiperazine self-assembly processes: Understanding the molecular events involved in Ne-(fumaroyl) diketopiperazine of L-Lys (FDKP) interactions. Kaur, N.; Zhou, B.; Breitbeil, F.; Hardy, K.; Kraft, K.S.; Trantcheva, I.; Phanstiel IV, O. Molecular Pharmaceutics, 2008, 5, No. 2, 294-315.
  • Designing the Polyamine Pharmacophore: Influence of N-substituents on the transport behavior of polyamine conjugates, Kaur, N.; Delcros, J-G.; Archer, J.; Weagraff, N.Z.; Martin, B.; Phanstiel IV, O. J. Med. Chem. 2008, 51, 2551-2560.
  • Chemoselective N-acylation via Condensations of N-(Benzoyloxy)amines and alpha-Ketophosphonic acids under Aqueous Conditions. Arora, J.S.; Kaur, N.; Phanstiel IV, O. J. Org. Chem. 2008, 73, 6182-6186.