About Muthu Periasamy, Ph.D

Dr. Periasamy received his PhD in Biochemistry, at the Universite’ de Montpellier located in France. He then pursued his extensive Post-doctoral research training, both at Albert Einstein’s college of Medicine and at Boston children’s Hospital / Harvard Medical School. He completed faculty appointments including Assistant and Associate Professor in the Department of Molecular Physiology and Biophysics at the University of Vermont, eventually progressing into the role of Professor and Director of Molecular Cardiology at the University of Cincinnati. In 2001 he was appointed Professor and Chair for the Department of Physiology & Cell Biology at Ohio State University, where he played a prominent role in building a thematic research program in Cardiac Muscle Physiology.

Dr. Periasamy joined the College of Medicine in 2018. He will be involved in research, teaching and training of graduate, undergraduate and medical students. His laboratory seeks to understand the factors that contribute to ageing induced muscle loss, dysfunction and diabetes. Dr. Periasamy has trained over 35 students and post-doctoral fellows and has significant experience in teaching, research, and mentorship.

Over the years, he has served on a number of university and advisory committees, including the role of President of the Associate of Chairs of Physiology Departments and Chair of NIH /AHA study committees. He has been invited to present on multiple occasions around the globe. Dr. Periasamy has been awarded numerous competitive grants for his research endeavors, exceeding a total of $17,000,000. He has also been awarded the AHA Established Investigator Award and been recipient of a number of honors and fellowships.

 

Recent Peer-Reviewed Publications:

  • Maurya SK, Herrera JL, Sahoo SK, Reis FCG, Vega RB, Kelly DP, Periasamy M. Sarcolipin signaling promotes mitochondrial biogenesis and oxidative metabolism in skeletal muscle. Cell Rep. 2018 Sep 11;24(11):2919-2931. doi: 10.1016/j.celrep.2018.08.036.
  • Periasamy M, Herrera JL, Reis FCG. Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism. Diabetes Metab J. 2017 Oct;41(5):327-336. doi:10.4093/dmj.2017.41.5.327.
  • Periasamy M, Maurya SK, Sahoo SK, Singh S, Sahoo SK, Reis FCG, Bal NC. Role of SERCA pump in muscle thermogenesis and metabolism. Compr Physiol. 2017 Jun 18;7(3):879-890. doi: 10.1002/cphy.c160030. PMID: 28640447.
  • VandeKopple MJ, Wu J, Baer LA, Bal NC, Maurya SK, Kalyanasundaram A, Periasamy M, Stanford KI, Giaccia AJ, Denko NC, Papandreou I. Stress-responsive HILPDA is necessary for thermoregulation during fasting. J Endocrinol. 2017 Oct;235(1):27-38. doi: 10.1530/JOE-17-0289. Epub 2017 Jul 24.PMID: 28739822.
  • Bal NC, Singh S, Reis FCG, Maurya SK, Pani S, Rowland LA, Periasamy M. Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice. J Biol Chem. 2017 Aug 9. pii: jbc.M117.790451. doi: 1074/jbc.M117. 790451. [Epub ahead of print] PMID:28794154
  • Pant, M; Bal, NC; Periasamy M. Sarcolipin: A key thermogenic and metabolic regulator in skeletal muscle. Trends Endocrinol Metab. 2016 Dec;27(12):881-892. DOI:10.1016/j.tem.2016.08.006
  • Schill KE, Altenberger AR, Lowe J, Periasamy M, Villamena FA, Rafael-Fortney JA, Devor ST. Muscle damage, metabolism, and oxidative stress in mdx mice: Impact of aerobic running. Muscle Nerve. 2016 Jun;54(1):110-117. doi: 10.1002/mus.25015. PubMed PMID: 26659868.
  • Bal NC, Maurya SK, Singh S, Wehrens XH, Periasamy M. Increased reliance on muscle-based thermogenesis upon acute minimization of brown adipose tissue function. J Biol Chem. 2016 Jun 13. pii: jbc.M116.728188. [Epub ahead of print] PubMed PMID: 27298322.
  • Rowland LA, Maurya SK, Bal NC, Kozak L, Periasamy M. Sarcolipin and uncoupling protein 1 play distinct roles in diet-induced thermogenesis and do not compensate for  one another. Obesity (Silver Spring). 2016 May 30. doi: 10.1002/oby.21542. [Epub ahead of print] PubMed PMID: 27238087.
  • Gaudet AD, Fonken LK, Gushchina LV, Aubrecht TG, Maurya SK, Periasamy M, Nelson RJ, Popovich PG. miR-155 Deletion in female mice prevents diet-induced obesity. Sci Rep. 2016 Mar 8; 6:22862. doi: 10.1038/srep22862. PubMed PMID: 26953132.