About David Harris, Ph.D

David Harris has been with the UCF College of Medicine since October 2011. Previously, he was Course Director of Medical Physiology at Drexel University College of Medicine.  His scientific background included research in heart failure and hypertension and has published in journals such as Lancet, Circulation, and the Proceedings of the National Academy of Sciences. His role at the College of Medicine is Director of the Structure and Function Module and is responsible primarily for the cardiovascular and pulmonary physiology components.  He currently mentors students from the FIRE module in his focus of study, medical education research.  He has strong interests in the use of high fidelity patient simulations with medical students and undergraduate students as well as active learning methodologies.  He has led workshops and symposia at the national level on the topics of simulation and small group learning. Dr. Harris is active in the American Physiological Society where has served on several committees and has won a New Research Investigator Award and a Teaching Career Enhancement Award. In 2018, he won the Early Career Award for Excellence in Teaching and Learning from the International Association of Medical Science Educators.  He is also a member of the leadership team for Aquifer Sciences (formerly MedU Science)  that aims to develop integrative tools for incorporation of basic science into the clinical years of medical education.  He serves as Associate Editor for Advances in Physiology Education and Medical Education Online and serves as an ad-hoc reviewer for Medical Science Educator, Studies in Higher Learning, and Advances in Medical Education and Practice to name a few.

 

  • Nguyen K, Khallouq BB, Schuster A, Beevers C, Dil N, Kay D, Kibble JD, Harris DM. Developing a tool for observing group critical thinking skills in first-year medical students: a pilot study using physiology-based, high fidelity patient simulation. Adv in Physio Educ, Vol 41(4), p. 604-611, December 2017.
  • Pasarica M, Harris DM, Franklin AL. Medical students teaching peer athletes: an innovative way of instructing the physiology of exercise, nutrition, and sleep as fundamentals for lifestyle medicine. Accepted into Adv in Physio Educ, Vol 41 (3), p. 432-435, September 2017.
  • Harris DM.  Simulation for Undergraduates: is there a worthy return on investment?  Adv in Physio Educ, Vol 40(4), p 472, December 2016.
  • Tsang A, Harris DM. Faculty and Second-Year Medical Student Perceptions of Active Learning in an Integrated Curriculum.  Adv in Physio Educ, Vol 40(4), p 446-453, December 2016.
  • Cramer N, Asmar A, Gorman L, Gros B, Harris D, Howard T, Husain M, Salazar S, Kibble J. Application of a utility analysis to evaluate a novel assessment tool for clinically-oriented physiology and pharmacology.  Adv in Physio Educ, Vol 40(3), p 304-312, September 2016. http://advan.physiology.org/content/40/3/304
  • Zhang X, Ai X, Nakayama H, Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, Chen X. Persistent increases in Ca influx through Cav1.2 shortens action potential and causes Ca overload-induced afterdepolarizations and arrhythmias. Basic Research in Cardiology, 111 (1), January 2016. http://link.springer.com/article/10.1007/s00395-015-0523-4
  • Gorman AL, Castiglioni A, Hernandez C, Asmar A, Cendan J, Harris D.  Using Preclinical High-Fidelity Medical Simulations to Integrate Pharmacology and Physiology with Clinical Sciences. Medical Science Educator, Vol. 25 (4), December 2015. http://link.springer.com/article/10.1007/s40670-015-0173-z
  • Reinemann J, LaBell K, Bellew C, Asmar A, Cendan J, Harris DM. Integration and Improvement of Teamwork Skills in First Year Medical Students by Using Physiology Based High Fidelity Patient Simulations, Medical Science Educator, Vol 25(4), p. 503-512, December 2015. http://link.springer.com/article/10.1007/s40670-015-0161-3
  • Harris DM, Payer A, Husain M, Cowan M. The Use of an E-Portfolio System for Integration in a Cadaver Autopsy Report accepted to Medical Science Educator (June 2015)
  • Laury-Kleintop L, Mulgrew J, Heletz I, Nedelcoviciu R, Chang M, Harris D, Koch Walter, Schneider M, Muller A, Prendergast, G. Cardiac Specific disruption of Bin1 in mice enables a model of stress- and age-associated dilated cardiomyopathy. Journal of Cellular Biochemistry, April 2015. http://resolver.flvc.org/ucf?sid=google&auinit=LD&aulast=Laury%E2%80%90Kleintop&atitle=Cardiac%E2%80%90Specific+Disruption+of+Bin1+in+Mice+Enables+a+Model+of+Stress%E2%80%90and+Age%E2%80%90Associated+Dilated+Cardiomyopathy&id=doi:10.1002/jcb.25198&title=Journal+of+cellular+biochemistry&volume=116&issue=11&date=2015&spage=2541&issn=0730-2312
  • Harris DM. Bellew C, Zheng ZJ, Cendan JC, Kibble JD. High Fidelity Patient Simulators to Expose Undergraduate Students to the Clinical Relevance of Physiology Concepts. Adv in Physio Educ, 2014, Dec38(4): 372-5..  (5-year Impact Factor:  1.825) (http://advan.physiology.org/content/38/4/372.full-text.pdf+html)
  • Salazar S, Borrero JL, Harris DM.  On Systolic Murmurs and Cardiovascular Physiologic Maneuvers.  Adv in Physio Educ, 2012, Dec 36:  251-56. (5-year Impact Factor:  1.825) (http://advan.physiology.org/content/36/4/251.full.pdf+html)
  • Harris DM, Ryan K, Rabuck C.  Using a High-Fidelity Patient Simulator with First-Year Medical Students to Facilitate Learning of Cardiovascular Function Curves.  Adv in Physio Educ, 2012, Sept 36:213-219. (5-year Impact Factor:  1.825) (http://advan.physiology.org/content/36/3/213.full.pdf+html)
  • Kerkela R, Boucher M, Zaka R, Gao E, Harris D, Piuhola J, Song J, Serpi R, Woulfe KC, Cheung JY, O’Leary E, Bonventre JV, Force T. Cytosolic phospholipase A(2)alpha protects against ischemia/reperfusion injury in the heart. Clin Transl Sci. 2011 Aug; 4(4): 236-42. (5-year Impact Factor:  2.38) (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170125/pdf/nihms294051.pdf)
  • Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR.  Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. J Mol Cell Cardiol, 2011 Mar; 50(3): 460-70. (5-year Impact Factor: 4.988) (http://www.sciencedirect.com/science/article/pii/S002228281000444X#)
  • Brinks H, Boucher M, Gao E, Chuprun JK, Pesant S, Raake P, Huang ZM, Wang X, Qiu G, Gumpert A, Harris DM, Eckhart AD, Most P, Koch WJ.  Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms. Circ Res. 2010 Oct 29;107(9): 1140-9. (5-year Impact Factor: 10.037) (http://circres.ahajournals.org/content/107/9/1140.long)
  • Zhang H, Chen X, Gao E, MacDonnell SM, Wang W, Kolpakov M, Nakayama H, Zhang X, Jaleel N, Harris DM, Li Y, Tang M, Berretta RM, Leri A, Kajstura J, Sabri A, Koch WJ, Molkentin JD, Houser SR.  Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction. Circ Res 2010 Sep 17; 107(6): 800-9. (5-year Impact Factor: 10.037) (http://circres.ahajournals.org/content/107/6/800.long)
  • Woulfe KC, Gao E, Lal H, Harris D, Fan Q, Vagnozzi R, DeCaul M, Shang X, Patel S, Woodgett JR, Force T, Zhou J.  Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo. Circ Res 2010 May 28; 106 (10): 1635-45 (5-year Impact Factor: 10.037) (http://circres.ahajournals.org/content/106/10/1635.long)
  • Cohn HI, Xi Y, Pesant S, Harris DM, Hyslop T, Falkner B, Eckhart AD. G protein-coupled receptor kinase 2 expression and activity are associated with blood pressure in black Americans. Hypertension. 2009 Jul; 54 (1): 71-6. (5-year Impact Factor: 6.643) (http://hyper.ahajournals.org/content/54/1/71.long)
  • Harris DM, Chen X, Pesant S, Cohn HI, MacDonnell SM, Boucher M, Vinge LE, Raake P, Moraca SR, Li D, Most P, Houser SR, Koch WJ, Eckhart AD. Inhibition of angiotensin I Gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure. J Mol Cell Cardiol. 2009 Jan; 46(1): 100-7. (5-year Impact Factor: 4.988) (http://www.sciencedirect.com/science/article/pii/S0022282808007104#)
  • Cohn HI, Harris DM, Pesant S, Pfeiffer M, Zhou RH, Koch WJ, Dorn GW 2nd, Eckhart AD. Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction. Am J Physiol Heart Circ Physiol. 2008 Oct; 295(4): H1695-704.  (5-year Impact Factor:3.878) (http://ajpheart.physiology.org/content/295/4/H1695)
  • Martini JS, Raake P, Vinge LE, DeGeorge BR Jr, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ.  Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proc Natl Acad Sci USA. 2008 Aug 26; 105(34)12457-62. (5-year Impact Factor: 9.737) (http://www.pnas.org/content/105/34/12457.full)
  • Harris DM, Cohn HI, Pesant S, Eckhart AD. GPCR Signalling in hypertension: role of GRKs. Clin Sci (Lond). 2008 Aug;115(3): 79-89. (5-year Impact Factor: 4.181) (http://www.clinsci.org/cs/115/0079/cs1150079.htm)
  • Chen X, Zhang X, Harris DM, Piacentino V 3rd, Berretta RM, Margulies KB, Houser SR. Reduced effects of BAY K 8644 on L-type Ca Current in failing human cardiac myocytes are related to abnormal adrenergic regulation. Am J Physiol Heart Circ Physiol. 2008 May;294(5): H2257-67. (5-year Impact Factor: 3.878) (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021380/)
  • DeGeorge BR Jr, Gao E, Boucher M, Vinge LE, Martini JS, Raake PW, Chuprun JK, Harris DM, Kim GW, Soltys S, Eckhart AD, Koch WJ.  Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress. Circulation. 2008 Mar 18;117(11): 1378-87. (5-year Impact Factor: 15.304)  (http://circ.ahajournals.org/content/117/11/1378.long)
  • Pleger ST, Harris DM, Shan C, Vinge LE, Chuprun JK, Berzins B, Pleger W, Druckman C, Volkers M, Heierhorst J, Oie E, Remppis A, Katus HA, Scalia R, Eckhart AD, Koch WJ, Most P. Endothelial S100A1 modulates vascular function via nitric oxide. Circ Res. 2008 Apr 11;102(7): 786-94. (5-year Impact Factor: 10.037) ( http://circres.ahajournals.org/content/102/7/786.long)
  • Chu TF, Rupnick MA, Kerkela R, Dallabrida SM, Zurakowski D, Nguyen L, Woulfe K, Pravda E, Cassiola F, Desai J, George S, Morgan JA, Harris DM, Ismail NS, Chen JH, Schoen FJ, Van den Abbeele AD, Demetri GD, Force T, Chen MH.  Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 2007 Dec 15; 370(9604): 2011-9. (5-year Impact Factor: 33.797)  (http://www.sciencedirect.com/science/article/pii/S0140673607618650)
  • Harris DM, Cohn HI, Pesant S, Zhou RH, Eckhart AD. Vascular smooth muscle G(q) signaling is involved in high blood pressure in both induced renal and genetic vascular smooth muscle-derived models of hypertension.  Am J Physiol Heart Circ Physiol. 2007 Nov;293(5): H3072-9.  (http://ajpheart.physiology.org/content/293/5/H3072)
  • MacDonnell SM, Kubo H, Harris DM, Chen X, Berretta RM, Barbe MF, Kolwicz S, Reger PO, Eckhart A, Renna BF, Koch WJ, Houser SR, Libonati JR. Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5): H3122-9. (5-year Impact Factor:3.878)  (http://ajpheart.physiology.org/content/293/5/H3122)
  • Chen X, Wilson RM, Kubo H, Berretta RM, Harris DM, Zhang X, Jaleel N, MacDonnell SM, Bearzi C, Tillmanns J, Trofimova I, Hosoda T, Mosna F, Cribbs L, Leri A, Kajstura J, Anversa P, Houser SR. Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties. Circ Res. 2007 Mar 2; 100(4): 536-44. (5-year Impact Factor: 10.037) (http://circres.ahajournals.org/content/100/4/536.long)
  • Mills GD, Harris DM, Chen X, Houser SR. Intracellular sodium determines frequency-dependent alterations in contractility in hypertrophied feline ventricular myocytes.  Am J Physiol Heart Circ Physiol. 2007 Feb;292(2): H1129-38. (5-year Impact Factor:3.878)  (http://ajpheart.physiology.org/content/292/2/H1129)
  • Mills GD, Kubo H, Harris DM, Berretta RM, Piacentino V 3rd, Houser SR. Phosphorylation of phospholamban at threonine-17 reduces cardiac adrenergic contractile responsiveness in chronic pressure overload-induced hypertrophy.  Am J Physiol Heart Circ Physiol. 2006 Jul;291(1): H61-70. (5-year Impact Factor:3.878) (http://ajpheart.physiology.org/content/291/1/H61)
  • Harris DM, Eckhart AD, Koch WJ. Galphaq and its Aktions. J Mol Cell Cardiol. 2006 May;40(5): 589-92. (5-year Impact Factor: 4.988)  (http://www.sciencedirect.com/science/article/pii/S0022282806000721)
  • Chen X, Zhang X, Kubo H, Harris DM, Mills GD, Moyer J, Berretta R, Potts ST, Marsh JD, Houser SR. Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial dependent apoptosis in ventricular myocytes. Circ Res 2005 Nov 11;97(10): 1009-17.  (5-year Impact Factor: 10.037) (http://circres.ahajournals.org/content/97/10/1009.full.pdf+html)
  • Keys JR, Zhou RH, Harris DM, Druckman CA, Eckhart AD. Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling. Circulation. 2005 Aug 23;112(8): 1145-53. (5-year Impact Factor: 15.304) (http://circ.ahajournals.org/content/112/8/1145.long)
  • Harris DM, Mills GD, Chen X, Kubo H, Berretta RM, Votaw VS, Santana LF, Houser SR. Alterations in early action potential repolarization causes localized failure of sarcoplasmic reticulum Ca2+ release. Circ Res. 2005 Mar 18; 96(5): 543-50. (5-year Impact Factor: 10.037)  (http://circres.ahajournals.org/content/96/5/543.long)


Publications (Innovative Interactive Educational Media) (Peer-reviewed)

  • Pasarica M, Harris DM, Simms-Cendan J, Gorman AL. Collaborative learning activity utilizing evidence-based medicine to improve medical student learning of the lifestyle management of obesity. MedEdPORTAL Publications. 2016;12:10426. http://dx.doi.org/10.15766/mep_2374-8265.10426
  • Life Science Teaching Resources Community (lifescitrc.org).  Povlow M, Harris DM.
  • “Job Aids for Physiology and Pathophysiology for Cases and Simulations.” #R10679 (2016)
  • American Physiological Society Archives of Teaching Resources“GI Transporter Animations” #R6146 (2012)