About Dr. Saleh A. Naser

We investigate the association of Mycobacterium avium subspecies paratuberculosis (MAP) with Crohn’s disease and Type I Diabetes based on molecular mimicry

The overall objective of our research program is to investigate the role of Mycobacterium avium subsp. paratuberculosis (MAP) in the etiology of Crohn’s disease and Type I Diabetes.

  1. Diagnosis: we developed nested PCR assay and have identified biomarkers to predict the presence of MAP in clinical samples.
  2. Pathogenesis: We are investigating MAP role in Crohn’s and Type I Diabetes in association with single nucleotide polymorphisms (SNPs) in disease-specific genes.
  3. Treatment: Our lab is the focal point in an international phase III clinical trial to treat Crohn’s patients with anti-MAP therapy.
  4. Funding: Our research program is currently funded from various sources.

Publications since 2014:

Role of PTPN2/22 polymorphisms in pathophysiology of Crohn’s disease.
Robert C Sharp, Shazia A Beg, and Saleh A Naser.
World J Gastroenterol. 2018 Feb 14; 24(6): 657–670.
doi:  10.3748/wjg.v24.i6.657
Inflammatory Diseases of the Gut.
Rohr Michael, Narasimhulu Chandrakala Aluganti, Sharma Dhara, Doomra Mitsushita, Riad Aladdin, Naser Saleh, and Parthasarathy Sampath.
Journal of Medicinal Food.
February 2018, 21(2): 113-126.
https://doi.org/10.1089/jmf.2017.0138
Polymorphisms in Protein Tyrosine Phosphatase Non-receptor type 2 and 22 (PTPN2/22) are linked to hyper-proliferative T-Cells, and susceptibility to Mycobacteria in rheumatoid arthritis RC Sharp, SA Beg, SAN Naser. Front. Cell. Infect. Microbiol. 8(11)1-17. doi: 10.3389/fcimb.2018.00011
The alternate effects of anti-TNFa therapeutics and their role in mycobacterial granulomatous infection in Crohn’s disease
A Qasem, AE Naser, SA Naser. Expert Review of Anti-infective Therapy.A single capsule formulation of RHB-104 demonstrates higher anti-microbial growth potency for effective treatment of Crohn’s disease associated with Mycobacterium avium subspecies paratuberculosis A Qasem, M Safavikhasraghi, SA Naser Gut Pathogens 2016:8 (1), 45
Oleuropein Is Responsible for the Major Anti-Inflammatory Effects of Olive Leaf Extract
Qabaha Khaled, AL-Rimawi Fuad, Qasem Ahmad, and Naser Saleh A.
Journal of Medicinal Food. November 2017. https://doi.org/10.1089/jmf.2017.0070
The Consensus from the Mycobacterium avium ssp. paratuberculosis (MAP) Conference 2017
JT Kuenstner, S Naser, W Chamberlin, T Borody, DY Graham, A McNees, …
Front. Public Health, 27 September 2017 | https://doi.org/10.3389/fpubh.2017.00208
MicroRNAs 33, 122, and 208: a potential novel targets in the treatment of obesity, diabetes, and heart-related diseases.
OA Alrob, S Khatib, SA Naser. Journal of Physiology and Biochemistry, 1-8, 2016
RHB-104 triple antibiotics combination in culture is bactericidal and should be effective for treatment of Crohn’s disease associated with Mycobacterium paratuberculosis
KP Alcedo, S Thanigachalam, SA Naser
Gut Pathogens 2016:8 (1), 32
Oxidative stress due to Mycobacterium avium subspecies paratuberculosis (MAP) infection upregulates selenium-dependent GPx activity
A Qasem, A Abdel-Aty, H Abu-Suwa, SA Naser
Gut pathogens 2016:8 (1), 1
Microbe detection via hybridizing magnetic relaxation nanosensors
S Naser, JM Perez, C Kaittanis (2015)
US Patent 9,109,249
Resolution of Crohn’s disease and complex regional pain syndrome following treatment of paratuberculosis
JT Kuenstner, W Chamberlin, SA Naser, MT Collins, CT Dow, JM Aitken, …
World J Gastroenterol 2015:21 (13), 4048-4062
Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn’s Disease
RC Sharp, M Abdulrahim, ES Naser, SA Naser
Frontiers in cellular and infection microbiology 2015:5
Domino effect of hypomagnesemia on the innate immunity of Crohn’s disease patients
SA Naser, A Abdelsalam, S Thanigachalam, AS Naser, K Alcedo
World journal of diabetes 2014:5 (4), 527
Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance
M Samsam, R Ahangari, SA Naser
World J Gastroenterol 2014:20 (29), 9942-9951
Mycobacterium avium subspecies paratuberculosis causes Crohn’s disease in some inflammatory bowel disease patients
SA Naser, SR Sagramsingh, AS Naser, S Thanigachalam
World J Gastroenterol 2014:20 (23), 7403-7415
Bactericidal and Therapeutic Effects of Pure Non-Pasteurized Honey on Mycobacterium avium Subspecies Paratuberculosis
SA Naser, SM Elwasila, K Alcedo, II Riley
Austin J Biomed Eng 2014:1 (2), 1009
Demographic and Blood Lipid Profiles in Correlation with Heart Attacks among Mediterraneans
K Qabaha, WA Hassan, H Mansour, S Thanigachalam, S Naser
Journal of Nutrition & Food Sciences 2014:4 (4), 1


For all the articles, you may find them at this link: 
Articles List