About Dr. Ken Teter

Studies the cell biology of AB-type protein toxins such as Shiga toxin, cholera toxin, and ricin.

My research program is focused on the cell biology of intoxication with AB-type protein toxins such as cholera toxin, Shiga toxin, and ricin.  These toxins are originally present in the extracellular milieu, but they attack targets within the cytosol of the host cell.  The toxins must therefore cross a membrane barrier in order to function.  A long-term goal of my laboratory is to elucidate the cellular events that allow toxin translocation, or entry, into the host cell cytosol.  If this process is understood at the molecular level, then rational therapies can be devised to block toxin translocation and, thus, productive intoxication.

Recent publications

  1. Taylor M, Burress H, Banerjee T, Ray S, Curtis D, Tatulian SA, and Teter K.  2014.  Substrate-Induced Unfolding of Protein Disulfide Isomerase Displaces the Cholera Toxin A1 Subunit from Its Holotoxin.  PLoS Pathogens, 10(2):e1003925
  2. 

Teter K.  2013. Toxin Instability and Its Role in Toxin Translocation from the Endoplasmic Reticulum to the Cytosol.  (Review)  Biomolecules  3:997-1029.
  3. Reddy S, Taylor M, Zhao M, Cherubin P, Geden S, Ray S, Francis DH, and Teter K.  2013.  Grape Extracts Inhibit Multiple Events in the Cell Biology of Cholera Intoxication.  PLOS ONE  8(9):e73390
  4. Ray S, Taylor M, Banerjee T, Tatulian SA, and Teter K.  2012.  Lipid Rafts Alter the Stability and Activity of the Cholera Toxin A1 Subunit.  J Biol Chem  287(36):30395-30405
  5. Tapia-Pastrana G, Chavez-Dueñas L, Lanz-Mendoza H, Teter K, and Navarro-Garcia F.  2012.  VirK is a Periplasmic Protein Required for Efficient Secretion of Pet from Enteroaggregative E. coli.  Infect Immun  80(7):2276-2285
  6. 

Taylor M, Banerjee T, VanBennekom N, and Teter K.  2012.  Detection of Toxin Translocation into the Host Cytosol by Surface Plasmon Resonance.  J Vis Exp  59: pii: 3686. doi: 10.3791/3686.
  7. Massey S, Burress H, Taylor M, Nemec KN, Ray S, Haslam DB, and Teter K.  2011.  Structural and Functional Interactions Between the Cholera Toxin A1 Subunit and ERdj3/HEDJ, a Chaperone of the Endoplasmic Reticulum.  Infect Immun  79(11):4739-4747.
  8. Ray S, Taylor M, Burlingame M, Tatulian SA, and Teter K.  2011.  Modulation of Toxin Stability by 4-Phenylbutyric Acid and Negatively Charged Phospholipids.  PLoS ONE  6(8):e23692
  9. 

Massey S, Quiñones B, and Teter K.  2011.  A cell-based fluorescent assay to detect the activity of Shiga toxin and other toxins that inhibit protein synthesis. Methods Mol Biol  739:49-59.
  10. Taylor M, Banerjee T, Ray S, Tatulian SA, and Teter K.  2011.  Protein Disulfide Isomerase Displaces the Cholera Toxin A1 Subunit from the Holotoxin Without Unfolding the A1 Subunit.  J Biol Chem  286(25):22090-22100.
  11. Taylor M, Banerjee T, Navarro-Garcia F, Huerta J, Massey S, Burlingame M, Tatulian SA, and Teter K.  2011.  A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication and Unfolding / Translocation of the Cholera Toxin A1 Subunit.  PLoS ONE  6(4):e18825.
  12. 

Kaittanis C, Banerjee T, Santra S, Santiesteban OJ, Teter K, and Perez JM.  2011.  Identification of Moecular-Mimicry-Based Ligands for Cholera Diagnostics using Magnetic Relaxation.  Bioconj Chem  22(2):307-314.
  13. Banerjee T, Pande A, Jobling MG, Taylor M, Massey S, Holmes RK, Tatulian SA, and Teter K.  2010.  Contribution of Subdomain Structure to the Thermal Stability of the Cholera Toxin A1 Subunit.  Biochemistry  49(41):8839-8846.
  14. Taylor M, Navarro-Garcia F, Huerta J, Burress H, Massey S, Ireton K, and Teter K.  2010.  Hsp90 is
Required for Transfer of the Cholera Toxin A1 Subunit from the Endoplasmic Reticulum to the Cytosol.  J Biol Chem  285(41):31261-31267.
  15. Navarro-Garcia F, Sonnested M, and Teter K.  2010.  Host-Toxin Interactions Involving EspC and Pet, Two Serine Protease Autotransporters of the Enterobacteriaceae.  (Review)  Toxins  2(5):1134-1147.
  16. Nemec, KN, Scaglione P, Navarro-García F, Huerta J, Tatulian SA, and Teter K.  2010.  A Host-Specific Factor is Necessary for Efficient Folding of the Autotransporter Plasmid-Encoded Toxin.  Biochimie  92(2):171-177.
  17. Massey S, Banerjee T, Pande AH, Taylor M, Tatulian SA, and Teter K.  2009.  Stabilization of the Tertiary Structure of the Cholera Toxin A1 Subunit Inhibits Toxin Dislocation and Cellular Intoxication.  J Mol Biol  393:1083-1096.
  18. Quinones B, Massey S, Friedman M, Swimley MS, and Teter K.  2009.  Novel Cell-Based Method to
Detect Shiga Toxin 2 from Escherichia coli O157:H7 and Inhibitors of Toxin Activity.  Appl Environ Microbiol  75(5):1410-1416.
  19. Guerra L, Nemec KN, Massey S, Tatulian SA, Thelestam M, Frisan T, and Teter K.   2009.  A Novel 
Mode of Translocation for Cytolethal Distending Toxin.  Biochim Biophys Acta  1793(3):489-495.

Note: red indicates UCF graduate student; blue indicates UCF undergraduate; green indicates high school student

Teaching Publications


  1. Moore SD and Teter K.  2014.  Group-Effort Applied Research (GEAR):  Expanding Opportunities for Undergraduate Research Through Original, Class-Based Research Projects.  Biochemistry and Molecular Biology Education.  42(4):331-338
  2. Borgon RA, Verity N, and Teter K.  2013.  PILOTing Undergraduate Students to Hands-On Teaching and Research Skills.  Journal of Microbiology & Biology Education.  14(1):35-46.
  3. 

Teter K and Engelking H.  2009.  A Career Opportunities in the Biomedical Sciences Seminar Series.  Focus on Microbiology Education  15(3):6-7.