Burnett School of Biomedical Sciences

Dr. Pappachan E. Kolattukudy

  • Department: Burnett School of Biomedical Sciences
  • Title: Professor
  • Office: BMS 136B
  • Phone: 407.823.1305
  • Fax: 407.823.0956
  • Email: PK@ucf.edu

Biography

This laboratory is involved in several research areas. The genomic and molecular basis of pathogen interaction with their hosts is one area. Mycobacterium tuberculosis, the causative agent of tuberculosis, a major human disease that accounts for than one quarter of all preventable adult deaths, has acquired multidrug resistance making discovery of new drug targets a critical need. The high content of unique complex lipids in the cell walls of this organism helps the pathogen evade the host defenses and antimycobacterial drugs. Synthesis of these lipids offer potential new targets. We are investigating the mycobacterial genes involved in pathogenesis, using gene knock out and other molecular and cell biological approaches.Molecular mechanisms involved in the development of cardiovascular disease is another area. The role of chemokine-induced gene expression changes involved in the development of cardiovascular diseases is being elucidated with transgenic animals and gene-chip technology. A novel cell death-inducing gene was recently discovered in this laboratory. How this gene product is involved in cardiovascular disease is being elucidated using molecular and cell biological approaches.Gene knock-out approaches in mice are being used to elucidate the functions of collapsin response mediator proteins (CRMPs), a class of cytoplasmic proteins possibly involved in axonal guidance.
Recent Publications

  1. Younce C, Kolattukudy P. MCP-1 Induced Protein Promotes Adipogenesis via Oxidative Stress, Endoplasmic Reticulum Stress and Autophagy. Cell Physiol Biochem. 2012 Jun 22;30(2):307-320.
  2. Camdessanché JP, Ferraud K, Boutahar N, Lassablière F, Mutter M, Touret M, Kolattukudy P, Honnorat J, Antoine JC. The Collapsin Response Mediator Protein 5 Onconeural Protein Is Expressed in Schwann Cells Under Axonal Signals and Regulates Axon-Schwann Cell Interactions. J Neuropathol Exp Neurol. 2012 Apr;71(4):298-311
  3. Yamashita N, Ohshima T, Nakamura F, Kolattukudy P, Honnorat J, Mikoshiba K, Goshima Y. Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Field Organization. J Neurosci. 2012 Jan 25;32(4):1360-1365.
  4. Kolattukudy PE, Niu J. Inflammation, Endoplasmic Reticulum Stress, Autophagy, and the Monocyte Chemoattractant Protein-1/CCR2 Pathway. Circ Res. 2012 Jan 6;110(1):174-89.
  5. Liang J, Wang J, Saad Y, Warble L, Becerra E, Kolattukudy PE. Participation of MCP-induced protein 1 in lipopolysaccharide preconditioning-induced ischemic stroke tolerance by regulating the expression of proinflammatory cytokines. J Neuroinflammation. 2011 Dec 24;8(1):182. [Epub ahead of print]
  6. Veyrac A, Reibel S, Sacquet J, Mutin M, Camdessanche JP, Kolattukudy P, Honnorat      J, Jourdan F.CRMP5 Regulates Generation and Survival of Newborn Neurons in Olfactory and    Hippocampal Neurogenic Areas of the Adult Mouse Brain.  PLoS One.2011;6(10):e23721. Epub 2011 Oct 4.
  7. Kangkai Wang, Jianli Niu, Hyunbae Kim, and Pappachan E. Kolattukudy. (2011)   Osteoclast precursor differentiation by MCPIP via oxidative stress, endoplasmic reticulum stress, and autophagy. J Mol Cell Biol 3, 360-368.
  8. Jaiyanth Daniel Heedia Maamar., Chirajyoti Deb., Tatiana D. Sirakova, Pappachan E.          Kolattukudy.  (2011) Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages. PLoS Pathog. 2011 Jun;7(6):e1002093. Epub 2011 Jun 23.
  9. Niu J, Wang K, Graham S, Azfer A, Kolattukudy PE (2011). MCP-1-induced protein attenuates endotoxin-induced myocardial dysfunction by suppressing cardiac NF-кB activation via inhibition of IкB kinase activation. J Mol Cell Cardiol. Volume 51, Issue 2, Pages 177-186
  10. Niu J, Wang K, Kolattukudy PE. (2011). Cerium oxide nanoparticles inhibits oxidative stress and NF-{kappa}B activation in H9c2 cardiomyocytes exposed to cigarette smoke extract. J Pharmacol Exp Ther. 338(1):53-61
  11. Yamashita N, Mosinger B, Roy A, Miyazaki M, Ugajin K, Nakamura F, Sasaki Y,  Yamaguchi K, Kolattukudy P, Goshima Y (2011). CRMP5 regulates dendritic development and synaptic plasticity in the cerebellar Purkinje cells. J Neurosci  31(5):1773-1779
  12. Liang J, Saad Y, Lei T, Wang J, Qi D, Yang Q, Kolattukudy P.E, Fu M (2010) MCP-induced protein 1 acts as a deubiquitinase to negatively regulate JNK and NF-κB signaling by targeting TRAF family. JEM 207(13):2959-2973.
  13. Younce CW, Wang K, Kolattukudy PE (2010) Hyperglycemia-induced cardiomyocyte death is mediated via MCP-1production and induction of a novel zinc-finger protein MCPIP. Cardiovascular Research 87(4):665-74.
  14. Verma D, Kanagaraj A, Jin S, Singh ND, Kolattukudy PE, Daniell H (2010) Chloroplast-derived enzyme cocktails hydrolyse lignocellulosic biomass and release fermentable sugars. Plant Biotechnol J. 8(3):332-50.
  15. Younce CW, Kolattukudy PE (2010) MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP. Biochem J. 426(1):43-53.
  16. Younce CW, Azfer A, Kolattukudy PE. (2009) Monocyte chemotactic protein-1 (MCP-1)-induced protein, a recently identified Zn-finger protein, induces adipogenesis in 3T3-L1 pre-adipocytes without peroxisome proliferator-activated receptor gamma. J Biol Chem. 284 (40): 27620-27628
  17. Chirajyoti Deb, Chang-Muk Lee, Vinod S. Dubey, Jaiyanth Daniel, Bassam Abomoelak, Tatiana D. Sirakova, Santosh Pawar, Linda Rogers, Pappachan E. Kolattukudy (2009) A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen. PloS ONE 4(6): e6077.
  18. Niu J and Kolattukudy P (2009). Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications. Clin Science. 117, 95-109.
  19. Vrotsos EG, Kolattukudy PE, Sugaya K (2009) MCP-1 involvement in glial differentiation of neuroprogenitor cells through APP signaling. Brain Res Bull.79(2):97-103
  20. Niu J, Azfer A, Wang K, Wang X, Kolattukudy PE (2009) Cardiac-targeted expression of soluble Fas attenuates doxorubicin-induced cardiotoxicity in mice. J Pharmacol Exp Ther. 328(3):740-8

For more publication information, please visit Pubmed.